A big image opens when the thumbnail is clicked.(nies-0102.jpg)
Strain number NIES-102  
Phylum Cyanophyta  
Class Cyanophyceae  
Scientific name Microcystis aeruginosa (Kützing) Lemmermann  
Synonym Microcystis ichthyoblabe Kützing; Microcystis novacekii (Komárek) Compère; Microcystis viridis (A.Brown) Lemmermann; Microcystis wesenbergii Komárek  
Former name Microcystis viridis (A.Brown) Lemmermann  
Common name Blue-green alga ; Cyanobacteria  
Locality (Date of collection) Lake Kasumigaura, Ibaraki, Japan (1982-09-**)  
Latitude / Longitude 36.0428477398 / 140.373233439 
Habitat (Isolation source) Freshwater (Lake water)  
History < Watanabe, Makoto M.  
Isolator (Date of isolation) Watanabe, Michiko H. (1982-09-**)  
Identified by Watanabe, Michiko H.  
State of strain Cryopreservation; Unialgal; Clonal; Axenic[2018 Feb]  
Culture condition
(Preculture condition)
Medium:  MA  
Temperature:  24 C
Light intensity:  14-17 µmol photons/m2/sec, L/D cycle:  10L:14D
Duration:  42 D  
Gene information Whole-genome ( AP019314 ) , 16S rRNA ( D89033 DQ648027 ) , cpcB, cpcA ( DQ648022 ) , 16S-ITS-23S ( AB638216 ) , 16S-ITS-23 ( AM773538 ) , ITS ( AB254443 ) , cas2 ( AB644436 ) , ftsZ ( AB324859 ) , glnA ( AB324938 ) , gltX ( AB325017 ) , gyrB ( AB014988 AB325096 ) , mcnC, mcnE ( AB481220 ) , mcyA ( AB110106 ) , mcyB ( EU151878 ) , mcyD ( AB110117 ) , mcyE ( AY382535 EU151892 ) , mcyG ( AB110128 ) , mcyJ ( AB110139 ) , mdnA ( FN667622 ) , mdnB ( FN668540 ) , pgi ( AB325175 ) , pirE ( JX129190 ) , recA ( AB325254 ) , rpoC1 ( AB333829 ) , tpi ( AB325333 ) , tufA ( EU151923 ) , dnaN, trp2, mcyJ ( AB254436 )  
Cell size (min - max) - 5 μm  
Characteristics Cyanobacterial water bloom (aoko) ; Toxicity ; microcystin (+) (Tanabe et al. 2009b) ; Genome decoded strain (Yamaguchi et al. 2020) ; ST10 (Tanabe et al. 2007)  
Other strain no. Other strain no. : K-MV-20  
Remarks Cryopreserved; Axenic; Toxicity; Unstable 
Dahedl, E. K. & Urakawa, H. 2023 Differential effects of hydrogen peroxide and L-lysine treatments on the growth of freshwater Cyanophyta and Chlorophyta. Ecologies, 4, 355-370.
Keywords: hydrogen peroxide; L-lysine; algaecide; Microcystis aeruginosa; cyanobacteria
Strain(s): 881028434325 
DOI: 10.3390/ecologies4020023

Entfellner, E., Baumann, K. B. L., Edwards, C., Kurmayer, R. 2023 High structural diversity of aeruginosins in bloom-Forming cyanobacteria of the genus Planktothrix as a consequence of multiple recombination events. Mar. Drugs, 21, 638 (article ID).
Keywords: horizontal gene transfer; chemical diversification; freshwater ecotypes; shallow waterbodies; deep waterbodies
Strain(s): 9810220429884324812549 
PubMed: 38132959
DOI: 10.3390/md21120638

Asada, Y., Kamizato, R., Miyoshi, T., Akiba, M. 2023 Competitive effects of Microcystis aeruginosa-produced organic matter on 2-methylisoborneol removal by powered activated carbon treatment under non-equilibrium conditions. J. JSCE, 79, 23-25005 (article ID) (in Japanese with English summary).
Keywords: Microcystis aeruginosa; Algal organic matter; Powdered activated carbon; 2-methylisoborneol; Competitive adsorption
Strain(s): 871026041053 
DOI: 10.2208/jscejj.23-25005

Watanabe, S., Matsunami, N., Okuma, I., Naythen, P. T., Fujibayashi, M., Iseri, Y., Hao, A., Kuba, T. 2022 Blue light irradiation increases the relative abundance of the diatom Nitzschia palea in co-culture with cyanobacterium Microcystis aeruginosa. Water Environ. Res., 94, e10707 (article ID).
Keywords: algae; competition; light-emitting diode; water blooms
Strain(s): 102 
PubMed: 35403347
DOI: 10.1002/wer.10707

Cao, H., Xu, D., Zhang, T., Ren, Q., Xiang, L., Ning, C., Zhang, Y., Gao, R. 2022 Comprehensive and functional analyses reveal the genomic diversity and potential toxicity of Microcystis. Harmful Algae, 113, 102186 (article ID).
Keywords: Microcystis; Pangenome; Toxicity; Diversity; Classification
Strain(s): 8810229884324812549 
PubMed: 35287927
DOI: 10.1016/j.hal.2022.102186

Lv, X., Cheng, Y., Zhang, S., Hu, Z., Xiao, P., Zhang, H., Geng, R., Renhui, L. 2022 Polyphasic characterization and taxonomic evaluation of a bloom-forming strain morphologically Rresembling Radiocystis fernandoi (Chroococcales, Cyanobacteria) from Lake Erhai, China. Diversity-Basel, 14, 816 (article ID).
Keywords: bloom; Microcystis; phylogeny; polyphasic approach; Radiocystis fernandoi; taxonomy
Strain(s): 102103111 
DOI: 10.3390/d14100816

Harada, K. 2022 Elucidation of phenomena involving cyanobacteria in freshwater ecosystem by chemically ecological approach. YAKUGAKU ZASSHI, 142, 39-64 (in Japanese with English summary).
Keywords: chemical ecology; water bloom, β-cyclocitral, density stress, quorum sensing
Strain(s): 102298843 
DOI: 10.1248/yakushi.21-00146

Chia, M. A., Ameh, I., George, K. C., Balogun, E. O., Akinyemi, S. A., Lorenzi, A. S. 2022 Genetic diversity of microcystin producers (cyanobacteria) and microcystin congeners in aquatic resources across Africa: A review paper. Toxins, 10, 772 (article ID).
Keywords: biological risk; cyanobacteria; cyanotoxin; water supply; African continent; molecular markers; mcy genes
Strain(s): 89102298843 
PubMed: 36548605
DOI: 10.3390/toxics10120772

Arii, S., Yamashita, R., Tsuji, K., Tomita, K., Hasegawa, M., Bober, B., Harada, K. 2021 Differences in susceptibility of cyanobacteria species to lytic volatile organic compounds and influence on seasonal succession. Chemosphere, 284, 131378 (article ID).
Keywords: Susceptibility; Volatile organic compounds (VOCs); β-Cyclocitral; Minimal inhibitory concentration (MIC); Seasonal succession
Strain(s): 10211229880884316421652167716961728 
PubMed: 34217930
DOI: 10.1016/j.chemosphere.2021.131378

Li, B., Li, J., An, G., Zhao, C., Wang, C. 2021 Long-term and strong suppression against Microcystis growth and microcystin-release by luteolin continuous-release microsphere: Optimal construction, characterization, effects and proteomic mechanisms. Water Res., 202, 117448 (article ID).
Keywords: Continuous-release microsphere; Long-term algicidal effect; Luteolin; Microcystin; Microcystis-dominated cyanobacterial bloom; Proteomic mechanism
Strain(s): 102298 
PubMed: 34364065
DOI: 10.1016/j.watres.2021.117448

Pham, T.-L., Tran, T. H. Y., Shimizu, K., Li, Q., Utsumi, M. 2021 Toxic cyanobacteria and microcystin dynamics in a tropical reservoir: assessing the influence of environmental variables. Environ. Sci. Pollut. Res., 28, 63544–63557.
Keywords: Harmful algae bloom; Cyanotoxins; Real-time PCR; Sediment
Strain(s): 101102 
PubMed: 32948940
DOI: 10.1007/s11356-020-10826-9

Erratt, K. J., Creed, I. F., Trick, C. G. 2020 Differential drawdown of ammonium, nitrate, and urea by freshwater chlorophytes and Cyanobacteria. J. Phycol., 56, 458-468.
Strain(s): 8890102843 
PubMed: 31875965
DOI: 10.1111/jpy.12960

Yamaguchi, H., Suzuki, S., Osana, Y., Kawachi, M. 2020 Genomic characteristics of the toxic bloom-forming cyanobacterium Microcystis aeruginosa NIES-102. J. Genomics, 8, 1-6.
Keywords: algal bloom; cyanobacteria; genome; microcystin; Microcystis aeruginosa; Lake Kasumigaura
Strain(s): 102 
PubMed: 31892993
DOI: 10.7150/jgen.40978

Pham, T.-L., Tran, T. H. Y., Hoang, N. S., Ngo, X. Q., Tran, T. T. 2020 Co-occurrence of microcystin-and geosminproducing cyanobacteria in the Tri An Reservoir, a drinking-water supply in Vietnam. Fundam. Appl. Limnol., 193, 299-311.
Keywords: taste and odor; off-flavor compound; earthy/muddy smell; cyanotoxin
Strain(s): 102 
DOI: 10.1127/fal/2020/1296

Asukabe, H., Akahori, S., Ueno, E., Nakayama, T., Yamashita, R., Arii, S., Harada, K., Imanishi, S. Y. 2020 Cyanobacterial classification with the toxicity using MALDI Biotyper. J. Am. Soc. Mass Spectrom., 31, 1572-1578.
Keywords: cyanobacteria; MALDI Biotyper; microcystins; profiling
Strain(s): 27394273818789100101102103104105107111112207208230266298416433478510512515592593604611808809835843846847905928931932945981989102510431058106110641068106910711076108510991101110511131115112611331134113511441157121516421643165216681672167316771678169820872131241226653708373337343736375537563757 
PubMed: 32501712
DOI: 10.1021/jasms.0c00148

Batista, A. M. M., Woodhouse, J. N., Grossart, H.-P., Giani, A. 2019 Methanogenic archaea associated to Microcystis sp. in field samples and in culture. Hydrobiologia, 831, 1–4.
Keywords: Cyanobacteria; Methanogenic archaea; Bacterial community composition; Microcystis sp.; Tropical reservoir
Strain(s): 1011021114 
DOI: 10.1007/s10750-018-3655-3

Tanabe, Y., Hodoki, Y., Sano, T., Tada, K., Watanabe, MM. 2018a Adaptation of the freshwater bloom-forming cyanobacterium Microcystis aeruginosa to brackish water is driven by recent horizontal transfer of sucrose genes. Front. Microbiol., 9, 1150 (article ID).
Keywords: Microcystis; bloom; salt tolerance; sucrose; genomics; brackish water; horizontal gene trasnfer; ecotype
Strain(s): 4487888990919899100101102103104105107108109112298299478604843901105010521059106310671069107010751076108510931094109811001101110211041105110611071108111311141115112211281130113111321134113911411142114311441150117011741175117611771179118111831185121112131214121512321234123812391252208820902091246524662467246824692470247124722473247524762477247824792480248124822483248424852486248724882489249024912492249424952546254725482549255025512552255325542555255625572558255925602561259225942595259625972598259926002601260226032604260526062607260826102611261226132617261826192620262126222623262426252626262826294234 
PubMed: 29922255
DOI: 10.3389/fmicb.2018.01150

Imanishi, S. Y., Nakayama, T., Asukabe, H., Harada, K. 2017 Application of MALDI Biotyper to cyanobacterial profiling. Rapid Commun. Mass Spectrom., 31, 325-332.
Strain(s): 738910210310711229861180880983584398910251043105810711099164216521672 
PubMed: 27862451
DOI: 10.1002/rcm.7793

Tomita, K., Hasegawa, M., Arii, S., Tsuji, K., Bober, B., Harada, K. 2016 Characteristic oxidation behavior of b-cyclocitral from the cyanobacterium Microcystis. Environ. Sci. Pollut. Res., 23, 11998-12006.
Keywords: b-cyclocitral; Oxidation; Acidification; Cyanobacteria; Blue color formation; Lysis
Strain(s): 102 
PubMed: 26961531
DOI: 10.1007/s11356-016-6369-y

Anas, A. R. J., Nakajima, A., Naruse, C., Tone, M., Asukabe, H., Harada, K. 2016 Determination of fVIIa-sTF inhibitors in toxic Microcystis cyanobacteria by LC-MS technique. Mar. Drugs, 14, 7 (article ID).
Keywords: cyanobacteria; toxic Microcystis; anticoagulant; fVIIa-sTF inhibitors; peptides; aeruginosins; blood coagulation cascade
Strain(s): 891021031072981025104310581071108510991133 
PubMed: 26729138
DOI: 10.3390/md14010007

Shimizu, K., Utsumi, M., Okano, K., Itayama, T., Iwami, N., Maseda, H., Kinohira, H., Li, J., Inamori, Y., Zhang, Z., Sugiura, N. 2016 Removal of Microcystis aeruginosa cells and microcystin-LR using ceramic carrier in a continuous flow bioreactor. Jpn. J. Water Treat. Biol., 52, 35-43.
Keywords: protozoa; water treatment; ceramic carrier; microcystin-producing; cyanobacteria
Strain(s): 102 

Kataoka, T., Homma, T., Nakano, S., Hodoki, Y., Ohbayashi, K., Kondo, R. 2013 PCR primers for selective detection of intra-species variations in the bloom-forming cyanobacterium, Microcystis. Harmful Algae, 23, 46-54.
Keywords: Microcystis aeruginosa; Quantitative PCR; 16S-23S rDNA ITS fegion; Selective detection; Intra-species variation
Strain(s): 4487909810110210310711111229860410621070 
DOI: 10.1016/j.hal.2012.12.003

Yoshida, T., Takashima, Y., Tomaru Y., Shirai, Y., Takao, Y., Hiroishi, S., Nagasaki, K. 2012 Intricate interactions between the bloom-forming cyanobacterium Microcystis aeruginosa and foreign genetic elements, revealed by diversified clustered regularly interspaced short palindromic repeat (CRISPR) signatures. Appl. Environ. Microbiol., 78, 5353-5360.
Strain(s): 87102298 
PubMed: 22636003
DOI: 10.1128/AEM.00626-12

Hodoki, Y., Ohbayashi, K., Kobayashi, Y., Okuda, N., Nakano, S. 2012 Detection and identification of potentially toxic cyanobacteria: Ubiquitous distribution of Microcystis aeruginosa and Cuspidothrix issatschenkoi in Japanese lakes. Harmful Algae, 16, 49-57.
Keywords: Anatoxin-a; Automated rRNA intergenic spacer analysis (ARISA); Cuspidothrix issatschenkoi; Cyanotoxin; Microcystin; Microcystis aeruginosa
Strain(s): 304077102111230512843905928932937991164516691698172919502116 
DOI: 10.1016/j.hal.2012.01.003

Tanabe, Y. & Watanabe, M. M. 2011 Local expansion of a panmictic lineage of water bloom-forming cyanobacterium Microcystis aeruginosa. PLoS One, 6, e17085 (article ID).
Strain(s): 4487888990919899100101102103104105106107108109110111112298299478604843901105010511052105310541055105610571058105910601061106210631064106510661067106810691070107210751076107710851090109110921093109410951096109710981100110111021103110411051106110711081113111411151122112311241125112611271128112911301131113211331134113511361137113811391140114111421143114411451146114711481149115011511152115311551156115711591160116111621163116411701171117211731174117511761177117911801181118311841185118612091211121312141215121612171218121912201221122212231224122512261227122812291230123112321233123412351236123712381239124012411242124312441245125112521253125420882089209020912465246624672468246924702471247224732474247524762477247824792480248124822483248424852486248724882489249024912492249324942495249625422543254425452546254725482549255025512552255325542555255625572558255925602561259125922593259425952596259725982599260026012602260326042605260626072608260926102611261226132617261826192620262126222623262426252626262726282629 
PubMed: 21390221
DOI: 10.1371/journal.pone.0017085

Shimada, K., Kitamura, N., Yoshida, Y., Matsushima, H., Asada, Y. 2010 Effects of water soluble extract from the dead leaves of deciduous trees on the growth control of toxic cyanobacteria like Microcystis aeruginosa. In Water Pollution X, Eds. by Marinov, A. M. & Brebbia, C. A., WIT Press, Bucharest. pp. 71-82.
Strain(s): 102 

Kuno, S., Yoshida, T., Kamikawa, R., Hosoda, N., Sako, Y. 2010 The distribution of a phage-related insertion sequence element in the cyanobacterium, Microcystis aeruginosa. Microbes Environ., 25, 295-301.
Keywords: cyanobacteria; Microcystis; cyanophage; insertion sequence; horizontal gene transfer
Strain(s): 90919899101102112298604843105810671070108610981105 
DOI: 10.1264/jsme2.ME10125

Ziemert, N., Ishida, K., Weiz, A., Hertweck, C., Dittmann, E. 2010 Exploiting the natural diversity of microviridin gene clusters for discovery of novel tricyclic depsipeptides. Appl. Environ. Microbiol., 76, 3568-3574.
Strain(s): 100101102843 
PubMed: 20363789
DOI: 10.1128/AEM.02858-09

Tanabe, Y., Sano, T., Kasai, F., Watanabe, M. M. 2009b Recombination, cryptic clades and neutral molecular divergence of the microcystin synthetase (mcy) genes of toxic cyanobacterium Microcystis aeruginosa. BMC Evol. Biol., 9, 115 (article ID).
Strain(s): 44878889909198991001011021031041051061071081091101111122982994786048439011050105110521053105410551056105710581059106010611062106310641065106610671068106910701072107510761077108510901091109210931094109510961097109811001101110211031104110511061107110811131114111511221123112411251126112711281129113011311132113311341135113611371138113911401141114211431144114511461147114811491150115111521153115511561157115911601161116211631164117011711172120912111213121412151216121712181219122012211222122312241225122612271228122912301231123212331234123512361237123812391240124112421243124412451251125212531254246524662467246924702471247224732474247524762477247824792561 
PubMed: 19463155
DOI: 10.1186/1471-2148-9-115

Ha, J. H., Hidaka, T., Tsuno, H. 2009 Quantification of toxic Microcystis and evolution of its dominance ratio in blooms using real-time PCR. Environ. Sci. Technol., 43, 812-818.
Strain(s): 102 
PubMed: 19245020
DOI: 10.1021/es801265f

Harada, K-I., Ozaki, K., Tsuzuki, S., Kato, H., Hasegawa, M., Kuroda, E. K., Arii, S., Tsuji, K. 2009 Blue color formation of cyanobacteria with b-cyclocitral. J. Chem. Ecol., 35, 1295-1301.
Keywords: b-cyclocitral; cyanobacteria; lysis; blue color formation; acid stress
Strain(s): 73102103112298611808 
PubMed: 19936836
DOI: 10.1007/s10886-009-9706-5

Ozaki, K., Ito, E., Tanabe, S., Natsume, K., Tsuji, K., Harada, K. 2009 Electron microscopic study on lysis of a cyanobacterium Microcystis. J. Health Sci., 55, 578-585.
Keywords: cyanobacteria; scanning electron microscope; transmission electron microscope; morphological change; b-cyclocitral; L-lysine
Strain(s): 102298 
DOI: 10.1248/jhs.55.578

Cadel-Six, S., Dauga, C., Castets, A. M., Rippka, R., Bouchier, C., de Marsac, N. T., Welker, M. 2008 Halogenase genes in nonribosomal peptide synthetase gene clusters of Microcystis (Cyanobacteria): sporadic distribution and evolution. Mol. Biol. Evol., 25, 2031-2041.
Keywords: halogenase; cyanopeptolin; aeruginosin; DNA rearrangement; secondary peptide metabolite; chlorination; internal transcribed spacer; phylogeny
Strain(s): 8998101102298 
PubMed: 18614525
DOI: 10.1093/molbev/msn150

Yoshida, M., Yoshida, T., Satomi, M., Takashima, Y., Hosoda, N., Hiroishi, S. 2008 Intra-specific phenotypic and genotypic variation in toxic cyanobacterial Microcystis aeruginosa. J. Appl. Phycol., 105, 407-415.
Keywords: API ZYM; diversity; microcystin; Microcystis; phylogeny; population; taxonomy; toxic; cyanobacteria
Strain(s): 101102103112298604105510581062107010911105 
DOI: 10.1111/j.1365-2672.2008.03754.x

Ozaki, K., Ohta, A., Iwata, C., Horikawa, A., Tsuji, K., Ito, E., Ikai, Y., Harada, K-I. 2008 Lysis of cyanobacteria with volatile organic compounds. Chemosphere, 71, 1531-1538.
Keywords: Cyanobacteria; Lysis; Microorganism; Volatile compound; b-Cyclocitral
Strain(s): 73102103112298 
PubMed: 18179811
DOI: 10.1016/j.chemosphere.2007.11.052

Nakasugi, K., Alexova, R., Svenson, C. J., Neilan, B. A. 2007 Functional Analysis of PilT from the Toxic Cyanobacterium Microcystis aeruginosa PCC 7806. J. Bacteriol., 189, 1689-1697.
Strain(s): 102 
PubMed: 17172325
DOI: 10.1128/JB.01640-06

Wu, Z. X., Gan, N. Q., Song, L. R. 2007 Genetic diversity: geographical distribution and toxin profiles of Microcystis strains (cyanobacteria) in China. J. Integr. Plant Biol., 49(3), 262-269.
Keywords: diversity; geographical distribution; microcystin; Microcystis
Strain(s): 98102 
DOI: 10.1111/j.1672-9072.2006.00368.x

Tanabe, Y., Kasai, F., Watanabe, M. M. 2007 Multilocus sequence typing (MLST) reveals high genetic diversity and clonal population structure of the toxic cyanobacterium Microcystis aeruginosa. Microbiology, 153, 3695-3703.
Strain(s): 44878889909198991001011021031041051061071081091101111122982994786048439019331050105110521053105410551056105710581059106010611062106310641065106610671068106910701072107510761077108510901091109210931094109510961097109811001101110211031104110511061107110811131114111511221123112411251126112711281129113011311132113311341135113611371138113911401141114211431144114511461147114811491150115111521153115511561157115911601161116211631164117011711172120912111213121412151216121712181219122012211222122312241225122612271228122912301231123212331234123512361237123812391240124112421243124412451251125212531254 
PubMed: 17975077
DOI: 10.1099/mic.0.2007/010645-0

Koskenniemi, K., Lyra, C., Rajaniemi-Wacklin, P., Jokela, J., Sivonen, K. 2007 Quantitative real-time PCR detection of toxic Nodularia cyanobacteria in the Baltic Sea. Appl. Environ. Microbiol., 73, 2173-2179.
Strain(s): 8189102 
PubMed: 17277219
DOI: 10.1128/AEM.02746-06

Kitamura, N., Nakagawa, T., Yoshida, Y., Matsushima, H., Asada, Y. 2006 Studies on the growth control of toxic cyanobacteria by use of the water-extracts from the dead leaves of deciduous trees. Environ. Eng. Res. [Kankyô-kôgaku Kenkyû Ronbunshû], 43, 543-549.
Keywords: growth control; Microcystis aeruginosa; dead-leaves; deciduous trees; condensed tannin
Strain(s): 102 
DOI: 10.11532/proes1992.43.543

Yoshida, T., Takashima, Y., Tomaru Y., Shirai, Y., Takao, Y., Hiroishi, S., Nagasaki, K. 2006 Isolation and characterization of a cyanophage infecting the toxic cyanobacterium Microcystis aeruginosa. Appl. Environ. Microbiol., 72, 1239-1247.
Strain(s): 44879098102104111112298604 
PubMed: 16461672
DOI: 10.1128/AEM.72.2.1239-1247.2006

Tanabe, Y., Kaya, K., Watanabe, M. M. 2004 Evidence for recombination in the microcystin synthetase (mcy) genes of toxic cyanobacteria Microcystis spp. J. Mol. Evol., 58, 633-641.
Keywords: cyanobacteria; microcystin synthetase; Microcystis; NRPS; recombination; split decomposition
Strain(s): 888990102103107 
PubMed: 15461420
DOI: 10.1007/s00239-004-2583-1

Takamura, Y., Yamada, T., Kimoto, A., Kanehama, N., Tanaka, T., Nakadaira, S., Yagi, O. 2004 Growth inhibiton of Microcystis cyanobacteria by L-lysine and disappearance of natural Microcystis blooms with spraying. Microbes Environ., 19, 31-39.
Keywords: Microcystis cyanobacteria; L-lysine; growth inhibition; water bloom; Euglena; Phormidium
Strain(s): 102 
DOI: 10.1264/jsme2.19.31

Hirabayashi, R. & Imamura, N. 2003 Action mechanism of a selective anti-cyanobacterial compound, argimicin A. J. Antibiotics, 56, 154-159.
Strain(s): 414581102204230298592 
PubMed: 12715875
DOI: 10.7164/antibiotics.56.154

Yamaguchi, T., Kobayashi, Y., Adachi, K., Imamura, N. 2003 Argimicins B and C, new anti-cyanobacterial compounds produced by Sphingomonas sp. M-17. J. Antibiot., 56, 655-657.
Strain(s): 4581102230298592 
PubMed: 14513910
DOI: 10.7164/antibiotics.56.655

Yoshida, T., Yuki, Y., Lei, S., Chinen, H., Yoshida, M., Kondo, R., Hiroishi, S. 2003 Quantitative detection of toxic strains of the cyanobacterial genus Microcystis by competitive PCR. Microbes Environ., 18, 16-23.
Keywords: competitive PCR; microcystin; Microcystis; peptide synthetase; toxic cyanobacteria
Strain(s): 87888990102104105106108109110111112298299604 
DOI: 10.1264/jsme2.18.16

Mori, F., Erata, M., Watanabe, M. M. 2002 Cryopreservation of cyanobacteria and green algae in the NIES-Collection. Microbiol. Cult. Coll., 18, 45-55.
Keywords: cryopreservation; cyanobacteria; green algae; FDA staining method; NIES-Collection
Strain(s): 192122232425262728293031323334353637383940414445465051525354555658596061626364656667686970737475767778798081878990919293949596979899100101102103104105106107108109110111112119120122123125127128129130131132133134135137138139144147151152153154155156157158159160162163164165166167168170171172173174175176177178179180181182183185186187188189191192193194197198199200201202203204205206207208209210211212213214215216217224226227228229230231232241242243244245246248257259261262263266267268287288289290294295297298299300301302303305306308309310312313329334337338339340341342349351359360361362375378379380382384385390394396397398415416418419421422423424425426427428429430431432433434436437438439440446447448449450451452453454455456457458459460464468469474478479480481503504505506507509510512514515522523524527528529530531532536537538539540541542543544545546564565566567568569570571572573574575576577578579580581582583584585592593594595596597598604610628630631632633634635636637638639640641642643644645646647648649650651652653654655656657658659660661662663664665666667672685686687688689690691692693694717718719720721722723724725726727728729 

Yuki, Y., Yoshida, T., Hiroishi, S. 2002 Molecular detection of the toxic cyanobacteria [Yûdoku aoko no bunshi-shikibetsu to yosatsu he-no ôyô]. In Series of Fisheries Science Vol. 143, Prevention and Extermination Strategies of Harmful Algal Blooms [Suisan-gaku shirîzu 134, Yûgai-yûdoku sôrui burûmu no yobô to kujo
] , Eds. by Hiroishi, S., Imai, I. & Ishimaru, T., Koseisha-Koseikaku, Tokyo, pp. 43-53 (in Japanese).
Strain(s): 738187888990919899100101102104105106108109110111112204230298299604 

Kodani, S., Imoto, A., Mitsutani, A., Murakami, M. 2002 Isolation and identification of the antialgal compound, harmane (1-methyl-B-carboline), produced by the algicidal bacterium, Pseudomonas sp. K44-1. J. Appl. Phycol., 14, 109-114.
Keywords: Algicidal bacteria; Antialgal compound; Cyanobacteria; Harmane; Pseudomonas sp.; Water bloom
Strain(s): 1923102227299446506 
DOI: 10.1023/A:1019533414018

Kameyama, K., Sugiura, N., Isoda, H., Inamori, Y., Maekawa, T. 2002 Effect of nitrate and phosphate concentration on production of microcystins by Microcystis viridis NIES 102. Aquat. Ecosyst. Health Manag., 5, 443–449.
Keywords: growth phase
Strain(s): 102 
DOI: 10.1080/14634980290001995

Imamura, N., Motoike, I., Shimada, N., Nishikori, M., Morisaki, H., Fukami, H. 2001 An efficient screening approach for anti-Microcystis compounds based on knowledge of aquatic microbial ecosystem. J. Antibiotics, 54, 582-587.
Strain(s): 102228 
PubMed: 11560377
DOI: 10.7164/antibiotics.54.582

Lyra, C., Suomalainen, S., Gugger, M., Vezie, C., Sundman, P., Paulin, L., Sivonen, K. 2001 Molecular characterization of planktic cyanobacteria of Anabaena, Aphanizomenon, Microcystis and Planktothrix genera. Int. J. Syst. Evol. Microbiol., 51, 13-526.
Keywords: cyanobacteria; 16S rRNA gene; RFLP; sequencing; REP; ERIC
Strain(s): 41447379818998102104 
DOI: 10.1099/00207713-51-2-513

Imamura, N., Motoike, I., Noda, M., Adachi, K., Konno, A., Fukami, H. 2000 Argimicin A, a novel anti-cyanobacterial compound produced by an algae-lysing bacterium. J. Antibiotics, 53, 1317-1319.
Strain(s): 102298 
DOI: 10.7164/antibiotics.53.1317

Kondo, R., Kagiya, G., Hiroishi, S., Watanabe, M. 2000 Genetic typing of a bloom-forming cyanobacterial genus Microcystis in Japan using 16S rRNA gene sequence analysis. Plankton Biol. Ecol., 47, 1-6.
Keywords: genetic typing; 16S rDNA; Microcystis; cyanobacteria; phylogenetic analysis
Strain(s): 878889909198991001011021041051061081091101111122982996041055106110681076109010911105112211421164 

Kondo, R., Kagiya, G., Komura, M., Yuki, Y., Hiroishi, S., Watanabe, M. 2000 Molecular taxonomy of a bloom-forming cyanobacterial genus Microcystis. Bull. Plankton Soc. Japan, 47, 25-33 (in Japanese with English summary).
Keywords: cyanobacteria; Microcystis; bacterial criteria; molecular analysis
Strain(s): 6878889909198991001011021041051061081091101111122982996041055106110681076109010911105112211421164 

Kondo, R., Yoshida, T., Yuki, Y., Hiroishi, S. 2000 DNA-DNA reassociation among a bloom-forming cyanobacterial genus, Microcystis. Int. J. Syst. Evol. Microbiol., 50, 767-770.
Keywords: DNA hybridization; DNA G+C content; cyanobacteria; Microcystis
Strain(s): 878998102104111112298604 
PubMed: 10758887
DOI: 10.1099/00207713-50-2-767

Metcalf, J. S., Bell, S. G., Codd, G. A. 2000 Production of novel polyclonal antibodies against the cyanobacterial toxin microcystin-LR and their application for the detection and quantification of microcystins and nodularin. Water Res., 34, 2761-2769.
Keywords: cyanobacteria; blue-green algae; microcystin; toxins; antibodies; immunoassays
Strain(s): 42102103104595 
DOI: 10.1016/S0043-1354(99)00429-7

Tillett, D., Neilan, B. A. 2000 Xanthogenate nucleic acid isolation from cultured and environmental cyanobacteria. J. Phycol., 36, 251-258.
Keywords: cyanobacteria; DNA extraction; nucleic acids; PCR; xanthogenate
Strain(s): 81102107 
DOI: 10.1046/j.1529-8817.2000.99079.x

Kondo, R., Kagiya, G., Hiroishi, S., Watanabe, M., Hata, Y. 1999 Rapid DNA extraction from a bloom-forming cyanobacterium. Microbes Environ., 14, 157-161.
Keywords: DNA extraction; PCR; Microcystis; cyanobacteria
Strain(s): 878889909198991001011021041051061081091101111122982996041055106110681076109010911105112211421164 
DOI: 10.1264/jsme2.14.157

Yamaguchi, M., Ogawa, T., Muramoto, K., Kamio, Y., Jimbo, M., Kamiya, H. 1999 Isolation and characterization of a mannan-binding lectin from the freshwater cyanobacterium (blue-green algae) Microcystis viridis. Biochem. Biophys. Res. Commun., 265, 703-708.
Keywords: Microcystis viridis; lectin; cyanobacterium; mannan-binding lectin; blue-green algae; hemaggulutinin
Strain(s): 102 
DOI: 10.1006/bbrc.1999.1749

Neilan, B. A., Dittmann, E., Rouhiainen, L., Bass, R. A., Schaub, V., Sivonen, K., Börner, T. 1999 Nonribosomal peptide synthesis and toxigenicity of Cyanobacteria. J. Bacteriol., 181, 4089-4097.
Strain(s): 19248199102107204 
PubMed: 10383979
DOI: 10.1128/JB.181.13.4089-4097.1999

Kondo, R., Kagiya, G., Yuki, Y., Hiroishi, S., Watanabe, M. 1998 Taxonomy of a bloom-forming cyanobacterial genus Microcystis. Nippon Suisan Gakkaishi, 64, 291-292 (in Japanese with English title).
Strain(s): 87888990919899100101102104105106107108109110111112298299604 

Li, R., Yokota, A., Sugiyama, J., Watanabe, M., Hiroki, M., Watanabe, M. M. 1998 Chemotaxonomy of planktonic cyanobacteria based on non-polar and 3-hydroxy fatty acid composition. Phycol. Res., 46, 21-28.
Keywords: 3-hydroxy fatty acids; chemotaxonomy; fatty acid; non-polar fatty acids; planktonic cyanobacteria
Strain(s): 2740447678798081878998102104111112204205207298604810821825826 
DOI: 10.1111/j.1440-1835.1998.tb00093.x

Sugiura, N., Iwami, N., Itayama, T., Inamori, Y. 1997 Population dynamics of grazer Monas guttula and prey Microcystis viridis using aquatic large scale microcosm. J. Jpn. Soc. Wat. Environ., 20, 332-337.
Keywords: disappearance process; grazer; Microcystis; microflagellate; large scale microcosm
Strain(s): 102 

Ward, C. J., Beattie, K. A., Lee, E. Y. C., Codd, G. A. 1997 Colorimetric protein phosphatase inhibition assay of laboratory strains and natural blooms of cyanobacteria: comparisons with high-performance liquid chromatographic analysis for microcystins. FEMS Mircobiol. Lett., 153, 465-473.
Keywords: Microcystin; Protein phosphatase; Cyanobacteria; High-performance liquid chromatography
Strain(s): 42102103104298595 
PubMed: 9271876
DOI: 10.1111/j.1574-6968.1997.tb12611.x

Forni, C., Telo, F. R., Caiola, M. G. 1997 Comparative analysis of the polysaccharides produced by different species of Microcystis (Chroococcales, Cyanophyta) . Phycologia, 36, 181-185.
Strain(s): 8798102112 
DOI: 10.2216/i0031-8884-36-3-181.1

Iwami, N., Inamori, Y., Sugiura, N., Matsumura, M. 1996 Degradation characteris-tics of toxic Microcystis viridis by Mastigophora, Monas guttula using aquatic large scale microcosm. J. Jpn. Soc. Wat. Environ., 19, 140-146.
Keywords: degradation; Microcystis; microflagellate; toxic substance; aquatic large scale microcosm
Strain(s): 102 

Matsuda, H., Okino, T., Murakami, M., Yamaguchi, K. 1996 Aeruginosins 102-A and B, new thrombin inhibitors from the cyanobacterium Microcystis viridis (NIES-102). Tetrahedron, 52, 14501-14506.
Strain(s): 102 
DOI: 10.1016/0040-4020(96)00890-3

Sakamoto, S., Yamaguchi, M., Watanabe, M. F., Watanabe, M., Kamiya, H. 1996 Distribution and characterization of lectins from natural and cultured Microcystis spp. In Harmful and Toxic Algal Blooms, Eds. by Yasumoto, T., Oshima, Y. & Fukuyo, Y., Intergovernmental Oceanographic Commission of UNESCO 1996, pp. 569-572.
Strain(s): 1001021062981057106110661080 

Neilan, B. A., Jacobs, D., Goodman, A. E. 1995 Genetic diversity and phylogeny of toxic cyanobacteria determined by DNA polymorphisms within the phycocyanin locus. Appl. Environ. Microbiol., 61, 3875-3883.
Strain(s): 244041447376788081878998102107111112204207298 
PubMed: 8526499

Neilan, B. A., Hawkins, P. R., Cox, P. T., Goodman, A. E. 1994 Towards a molecular taxonomy for the bloom-forming cyanobacteria. Aust. J. Mar. Freshwater Res., 45, 869-873.
Keywords: 16S rRNA; PCR; Microcystis; Anabaena; DNA sequence
Strain(s): 417889102107111 
DOI: 10.1071/MF9940869

Kasai, F., Takamura, N., Hatakeyama, S. 1993 Effects of simetryne on growth of various freshwater algal taxa. Environ. Pollut., 79, 77-83.
Strain(s): 35447377102137151230231255275280298 
DOI: 10.1016/0269-7491(93)90180-V

Inamori, Y., Ohno, Y., Kaya, K., Watanabe, M. M., Sudo, R. 1990 Studies on the removal and decomposition of Microcystis viridis toxic substance in the bio-film reactor. Jpn. J. Water Poll. Res., 13, 525-530 (in Japanese with English summary).
Keywords: Microcystis viridis; toxic substance cyanoviridin; bio-film reactor; hydraulic retention time
Strain(s): 102 

Ishitsuka, M. O., Kusumi, T., Kakisawa, H., Kaya, K., Watanabe, M. M. 1990 Microviridin: a novel tricyclic depsipeptide from the toxic cyanobacterium Microcystis viridis. J. Am. Chem. Soc., 112, 8180-8182.
Strain(s): 102 

Kaya, K. & Watanabe, M. M. 1990 Microcystin composition of an axenic clonal strain of Microcystis viridis and Microcystis viridis-containing waterblooms in Japanese freshwaters. J. Appl. Phycol., 2, 173-178.
Keywords: axenic Microcystis viridis; microcystin; toxic waterbloom; Japanese lakes
Strain(s): 102 
DOI: 10.1007/BF00023379

Sugaya, Y., Yasuno, M., Yanai, T. 1990 Effects of toxic Microcystis viridis and isolated toxins on goldfish. Jpn. J. Limnol., 51, 149-153.
Keywords: fish; hepatotoxin; Microcystis; hemorrhage
Strain(s): 102 

Yamamoto, Y. & Suzuki, K. 1990 Distribution and algal-lysing activity of fruiting myxobacteria in Lake Suwa. J. Phycol., 26, 457-462.
Keywords: algal-lysing activity; cyanobacteria; fruiting myxobacteria
Strain(s): 19404499102112 
DOI: 10.1111/j.0022-3646.1990.00457.x

Ooi, T., Kusumi, T., Kakisawa, H., Watanabe, M. M. 1989 Structure of cyanoviridin RR, a toxin from the blue-green alga, Microcystis viridis. J. Appl. Phycol., 1, 31-38.
Keywords: blue-green alga; Microcystis viridis; cyanoviridin RR; microcystin RR, toxins
Strain(s): 102 

Watanabe, M. M. 1989 Toxicity of algae [Sôrui no dokusei]. Jpn. J. Water Poll. Res., 12, 750-756 (in Japanese).
Strain(s): 102 

Yamaguchi, K., Murakami, M., Okino, T. 1989 Screening of angiotensin-converting enzyme inhibitory activities in microalgae. J. Appl. Phycol., 1, 271-275.
Keywords: angiotensin converting enzyme; inhibitor; microalgae; peptide; screening
Strain(s): 14100102104114 

Kusumi, T., Ooi, T., Watanabe, M. M. Takahashi, H., Kakisawa, H. 1987 Cyanoviridin RR, a toxin from the cyanobacterium (blue-green alga) Microcystis viridis. Tetrahedron Letters, 28, 4695-4698.
Strain(s): 102 
DOI: 10.1016/S0040-4039(00)96600-0

Watanabe, M. M., Suda, S., Kasai, F., Sawaguchi, T. 1985 Axenic cultures of the three species of Microcystis (Cyanophyta = Cyanobacteria). Bull. JFCC, 1, 57-63.
Strain(s): 89102107111298 

Unauthorized copying and replication of text, images, and tables in our homepage, are prohibited.