Strain Data

A big image opens when the thumbnail is clicked.(nies-0144.jpg)
Strain number NIES-144  
Phylum Chlorophyta  
Class Chlorophyceae  
Scientific name Haematococcus lacustris (Girod-Chantrans) Rostafinski  
Synonym Volvox lacustris Gir.-Chantr. 1802; Sphaerella lacustris (Gir.-Chantr.) Wittr. ex Hansg. 1888; Lepraria kermesina Wrangel 1824; Sphaerella wrangelii Sommerf. 1824, nom. illeg.; Chlorococcum kermesinum (Wrangel) Fr. 1825; Protococcus kermesinus (Wrangel) C.Agardh 1825; Byssus kermesinum (Wrangel) Wahlenb. 1826; Globulina kermesinum (Wrangel) Turpin 1836; Haematococcus kermesinus (Wrangel) Flot. 1844; Protococcus monospermus Corda 1833; Haematococcus cordae Menegh. 1844; Protosphaeria cordae (Menegh.) Trevis. 1848; Disceraea purpurea Morren & C.Morren 1841; Haematococcus pluvialis Flot. 1844; Protococcus pluvialis (Flot.) Kütz. 1845; Protosphaeria pluvialis (Flot.) Trevis. 1848; Chlamydococcus pluvialis (Flot.) A.Braun 1850 (“1849”); Hysginum pluviale (Flot.) Perty 1852; Sphaerella pluvialis (Flot.) Wittr. 1886; Haematococcus longistigma H.Ettl 1954; Haematococcus buetschlii var. bahusiensis Skuja 1956  
Former name  
Common name Green alga  
Locality (Date of collection) Sapporo, Hokkaido, Japan (1964-07-16)  
Latitude / Longitude  
Habitat (Isolation source) Freshwater (Lake water)  
History < IAM (1983);  
Isolator (Date of isolation) Ichimura, Terunobu (1964-07-16)  
Identified by Ichimura, Terunobu  
State of strain Cryopreservation; Unialgal; Clonal; Axenic[2013 Jan]  
Culture condition
(Preculture condition) 		Medium:  C (agar)  
Temperature:  20 (25) C
Light intensity:  2 (14-16) µmol photons/m2/sec, L/D cycle:  10L:14D
Duration:  4 M (14 D)  
Gene information Whole-genome ( BLLF00000000 ) , 18S rRNA ( AB360747 ) , atpB ( AB084325 ) , psaB ( AB084365 ) , rbcL ( AB084336 AB084337 ) , bkt3 ( AY603347 ) , lycopene beta-cyclase ( AY182008 ) , idi ( AB019034 ) , Hsp90 ( JN627245 ) , 14-3-3 protein ( AY973204 ) , beta-carotene ketolase ( D45881 )  
Cell size (min - max) 15 - 35 μm  
Organization Unicellular 
Characteristics Astaxanthin production ; Genome decoded strain (Morimoto et al. 2017) ; Homothallic ; Isogamous  
Other strain no. Other collection strain no. : IAM C-392
Other strain no. : MKF-8  
Remarks Cryopreserved; Axenic 
Movie  
Reference
Lee, J. Y., Lee, J. S., Sim, L. S. 2024 Enhanced toxicity-free astaxanthin extraction from Haematococcus pluvialis via concurrent cell disruption and demulsification. Bioresour. Technol., 406, 130974 (article ID).
Keywords: Haematococcus pluvialis; Astaxanthin recovery; Aqueous extraction; Demulsification
Strain(s): 144 
DOI: 10.1016/j.biortech.2024.130974

Azizi, M., Moteshafi, H., Hashemi, M. 2024 Novel paradigm of light and CO2 feeding to improve the co-production of ‎astaxanthin and polyunsaturated fatty acids in Haematococcus ‎pluvialis. J. CO2 Util., 84, 102855 (article ID).
Keywords: Haematococcus pluvialis; Lighting/CO2 balance; Astaxanthin; Polyunsaturated fatty acids; Carbon bio-sequestration
Strain(s): 144 
DOI: 10.1016/j.jcou.2024.102855

Gao, S., Pittman, K., Edmundson, S., Huesemann, M., Greer, M., Louie, W., Chen, P., Nobles, D., Benemann, J., Crowe, B. 2023 A newly isolated alkaliphilic cyanobacterium for biomass production with direct air CO2 capture. J. CO2 Util., 69, 102399 (article ID).
Keywords: Alkaliphilic cyanobacteria; Biomass; Raceway pond; Direct air capture
Strain(s): 144 
DOI: 10.1016/j.jcou.2023.102399

Saito, M., Watanabe, H., Sasaki, M., Ookubo, M., Yarita, T., Shiraiwa, M., Asayama, M. 2023 Coproduction of lipids and carotenoids by the novel green alga Coelastrella sp. depending on cultivation conditions. Biotech. Rep., 37, e00769 (article ID).
Keywords: biorefinery; carotenoid; Coelastrella; dual production; lipid
Strain(s): 144 
PubMed: 36660172
DOI: 10.1016/j.btre.2022.e00769

Xing, H., Li, Q., Zhao, Y., Gao, H., Li, L., Zhang, Y., Yu, X. 2023 Exogenous proline boosts the co-accumulation of astaxanthin and biomass in stress-induced Haematococcus pluvialis. Bioresour. Technol., 369, 128488 (article ID).
Keywords: Haematococcus pluvialis; Proline; Biomass; Astaxanthin productivity; Abiotic stresses
Strain(s): 144,  712,  797 
PubMed: 36528181
DOI: 10.1016/j.biortech.2022.128488

Joun, J., Sirohi, R., Sim, S. J. 2023 The effects of acetate and glucose on carbon fixation and carbon utilization in mixotrophy of Haematococcus pluvialis. Bioresour. Technol., 367, 128218 (article ID).
Keywords: Haematococcus pluvialis; Mixotrophy; Sodium acetate; Glucose; Mixotrophic metabolism
Strain(s): 144 
PubMed: 36332870
DOI: 10.1016/j.biortech.2022.128218

Ma, H., Zheng, J., Li, Y., Zhao, L., Zou, S., Hu, Q., Ha,n D. 2023 A novel bifunctional wax ester synthase involved in early triacylglycerol accumulation in unicellular green microalga Haematococcus pluvialis under high light stress. Front. Bioeng. Biotechnol., 9, 794714 (article ID).
Keywords: triacylglycerol; wax synthase; microalgae; bifunctional; Haematococcus pluvialis; biotechnological application
Strain(s): 144 
PubMed: 35111735
DOI: 10.3389/fbioe.2021.794714

Velmurugan, A. & Muthukaliannan, G. K. 2023 Homologous and heterologous expression of phytoene synthase gene in marine microalgae Dunaliella salina and its potential as aquaculture feed. Aquac. Int., 31, 3125–3144.
Keywords: Dunaliella salina; Phytoene synthase; Overexpression; Electroporation; β-carotene
Strain(s): 144 
DOI: 10.1007/s10499-023-01195-4

Sung, Y. J., Joun, J., Yu, B. S., Sim, S. J. 2023 Chapter 10 - Photobioreactor systems for production of astaxanthin from microalgae. In Current Developments in Biotechnology and Bioengineering. Photobioreactors : Design and Applications, Sirohi, R., Pandey, A., Sim, S., Chang, J.-S., Lee, D.-J., Elsevier pp. 229-246.
Strain(s): 144 
DOI: 10.1016/B978-0-323-99911-3.00005-1

Yang, H. E., Yu, B. S., Sim, S. J. 2023 Enhanced astaxanthin production of Haematococcus pluvialis strains induced salt and high light resistance with gamma irradiation. Bioresour. Technol., 372, 128651 (article ID).
Keywords: Haematococcus pluvialis Strain(s): 144 
PubMed: 36682476
DOI: 10.1016/j.biortech.2023.128651

Myint, A. A., Hariyanto, P., Irshad, M., Ruqian, C., Wulandari, S., Hong, M. E., Sim, S. J., Kim, J. 2022 Strategy for high-yield astaxanthin recovery directly from wet Haematococcus pluvialis without pretreatment. Bioresour. Technol., 346, 126616 (article ID).
Keywords: Haematococcus pluvialis; Astaxanthin; Wet ball mill extraction; Antioxidant activities
Strain(s): 144 
PubMed: 34954361
DOI: 10.1016/j.biortech.2021.126616

Lee, N., Narasimhan, A. L., Moon, G., Kim, Y.-E., Park, M., Kim, B., Mahadi, R., Chung, S., Oh, Y.-K. 2022 Room-temperature cell disruption and astaxanthin recovery from Haematococcus lacustris cysts using ultrathin α-quartz nanoplates and ionic liquids. Appl. Sci.-Basel, 12, 2210 (article ID).
Keywords: microalgae; Haematococcus lacustris; astaxanthin; ionic liquid; nanoplate; cell disruption; room-temperature extraction
Strain(s): 144 
DOI: 10.3390/app12042210

Lee, S.-A., Lim, W.-H., Ko, S.-R., Kim, B., Oh, H.-M., Ahn, C.-Y. 2022 Lifespan extension and anti-oxidant effects of carotenoid pigments in Caenorhabditis elegans. Bioresour. Technol. Reports, 17, 100962 (article ID).
Keywords: Haematococcus lacustris; Carotenoids; Caenorhabditis elegans; Lifespan; Antioxidation
Strain(s): 144 
DOI: 10.1016/j.biteb.2022.100962

Lee, K. H., Chun, Y., Lee, J. H., Park, C., Yoo, H. Y., Kwak, H. S. 2022 Improved productivity of astaxanthin from photosensitive Haematococcus pluvialis using phototaxis technology. Mar. Drugs, 20, (article ID).
Keywords: Haematococcus pluvialis; astaxanthin; photosynthetic efficiency; microfluidics; photobioreactor
Strain(s): 144 
PubMed: 35447893
DOI: 10.3390/md20040220

Han, S.-I., Jeon, M. S., Ahn, J.-W., Choi, Y.-E. 2022 Establishment of ultrasonic stimulation to enhance growth of Haematococcus lacustris. Bioresour. Technol., 360, 127525 (article ID).
Keywords: Haematococcus lacustris; Astaxanthin; Ultrasonication; Cell division
Strain(s): 144 
PubMed: 35760247
DOI: 10.1016/j.biortech.2022.127525

Ueda, R. & MWakisaka, M. 2022 Effect of melatonin as a bio-stimulant of astaxanthin production from Haematococcus. J. Jpn. Inst. Energy, 101, 132-137 (in Japanese with English summary).
Keywords: Astaxanthin; Bio stimulant; Haematococcus lacustris; Melatonin
Strain(s): 144 
DOI: 10.3775/jie.101.132

Lee, S.-A., Kim, M., Esterhuizen, M., Le, V. V., Kang, M., o, S.-R., Oh, H.-M., Kim, Y. J., Ahn, C.-Y. 2022 An acceleration of carotenoid production and growth of Haematococcus lacustris induced by host-microbiota network interaction. Microbiol. Res., 262, 127097 (article ID).
Keywords: Haematococcus lacustris; Astaxanthin; NGS; Phycosphere
Strain(s): 144 
PubMed: 35751943
DOI: 10.1016/j.micres.2022.127097

Mahadi, R., Vahisan, L. P. S., Ilhamsyah, D. P. A., Kim, S., Kim, B., Lee, N., Oh, Y.-K. 2022 Enhancement of astaxanthin and fatty acid production in Haematococcus pluvialis using strigolactone. Appl. Sci.-Basel, 12, 1791 (article ID).
Keywords: strigolactone; Haematococcus pluvialis; astaxanthin; fatty acid; phytohormone; rac-GR24
Strain(s): 144 
DOI: 10.3390/app12041791

Yoshino, T., Mao, Y., Maeda, Y., Negishi, R., Murata, S., Moriya, S., Shimada, H., Arakaki, A., Kobayashi, K., Hagiwara, Y., Okamoto, K., Tanaka, T. 2022 Single-cell genotyping of phytoplankton from oceanwater by gel-based cellmanipulation. Biotechnol. J., 17, 2100633 (article ID).
Keywords: gel-based cell manipulation; microcavity array; phytoplankton; single-cell; whole genome amplificatio
Strain(s): 144,  385,  2145 
PubMed: 35195355
DOI: 10.1002/biot.202100633

Örs, E. D., Alkan, S. B., Öksüz, A. 2022 Possible effect of astaxanthin on obesity-related increased COVID-19 infection morbidity and mortality. Curr. Nutr. Food Sci., 18, 265-273.
Keywords: Haematococcus pluvialis; Obesity; adipose tissue; astaxanthin; coronavirus disease 2019; inflammation
Strain(s): 144 
DOI: 10.2174/1573401317666211011105732

Villanueva, E. M. F. et al. 2022 Protist.guru: A Comparative Transcriptomics Database for Protists. J. Mol. Biol., 434, 167502 (article ID).
Strain(s): 144 
PubMed: 35389344
DOI: 10.1016/j.jmb.2022.167502

Kumar, S., Kumar, R., Diksha, Kumari, A., Panwar, A. 2022 Astaxanthin: A super antioxidant from microalgae and its therapeutic potential. J. Basic Microbiol., 62, 1064-1082.
Keywords: biological activities; cultivation system, biorefining proces
Strain(s): 144 
PubMed: 34817092
DOI: 10.1002/jobm.202100391

Moon, G., Lee, N., Kang, S., Park, J., Kim, Y.-E., Oh, Y.-K., Chung, S. 2021 Hydrothermal synthesis of novel two-dimensional α-quartz nanoplates and their applications in energy-saving, high-efficiency, microalgal biorefineries. Chem. Eng. J., 413, 127467 (article ID).
Keywords: α-Quartz; Nanoplates; Hydrothermal; Microalgae; Biorefinery
Strain(s): 144 
DOI: 10.1016/j.cej.2020.127467

Patel, A. K., Singhania, R. R., Sim, S. J., Dong, C. D. 2021 Recent advancements in mixotrophic bioprocessing for production of high value microalgal products. Bioresour. Technol., 320, 124421 (article ID).
Keywords: Microalgae; Mixotrophic; MCS; Organic carbon; Photosynthesis; Bioproducts
Strain(s): 144 
PubMed: 33246239
DOI: 10.1016/j.biortech.2020.124421

Matsuzaki, R., Suzuki, S., Yamaguchi, H., Kawachi, M., Kanesaki, Y., Yoshikawa, H., Mori, T., Nozaki, H. 2021 The Rubisco small subunits in the green algal genus Chloromonas provide insights into evolutionary loss of the eukaryotic carbon-concentrating organelle, the pyrenoid. BMC Ecol. Evol., 21, 11 (article ID).
Keywords: Chloromonas; Evolution; Green algae; Hydrophobicity of RBCS helices; Pyrenoid; Pyrenoid loss; Rubisco small subunit (RBCS)
Strain(s): 144,  424,  425,  2207,  2212,  2215,  2242,  2243,  2499,  3753,  4284 
PubMed: 33514317
DOI: 10.1186/s12862-020-01733-1

Fitriana, H.-N., Lee, S.-Y., Choi, S.-A., Lee, J.-Y., Kim, B.-L., Lee, J.-S., Oh, Y.-K. 2021 Electric stimulation of astaxanthin biosynthesis in Haematococcus pluvialis. Appl. Sci., 11, 3384 (article ID).
Keywords: microalgae; Haematococcus pluvialis; astaxanthin; electric treatment; stimulation; stress
Strain(s): 144 
DOI: 10.3390/app11083348


Strain(s): 24,  47,  144,  2146,  2160 

Abd Karim, F. F., Mohamad, S. E., Shaza, E. M., Iwamoto, K. 2021 Initial study on the growth of Haematococus pluvialis for astaxanthin production. IOP Conf. Ser.: Earth Environ. Sci., 765, 012064 (article ID).
Strain(s): 144 
DOI: 10.1088/1755-1315/765/1/012064

Cho, S. J., Sung, Y. J., Lee, J. S., Yu, B. S., Sim, S. J. 2021 Robust cyst germination induction in Haematococcus pluvialis to enhance astaxanthin productivity in a semi-continuous outdoor culture system using power plant flue gas. Bioresour. Technol., 338, 125533 (article ID).
Keywords: Haematococcus pluvialis; Astaxanthin; Cyst germination; Outdoor semi-continuous culture; Power plant flue gas
Strain(s): 144 
PubMed: 34284295
DOI: 10.1016/j.biortech.2021.125533

Yu, B. S., Sung, Y. J., Choi, H. I., Sirohi, R., Sim, S. J. 2021 Concurrent enhancement of CO2 fixation and productivities of omega-3 fatty acids and astaxanthin in Haematococcus pluvialis culture via calcium-mediated homeoviscous adaptation and biomineralization. Bioresour. Technol., 340, 125720 (article ID).
Keywords: Haematococcus pluvialis; Biomineralization; Omega-3 fatty acids; Astaxanthin
Strain(s): 144 
PubMed: 34365300
DOI: 10.1016/j.biortech.2021.125720

Sun, H., Wu, T., Chen, H Y., Ren, Y., Yang, S., Huang, J., Mou, H., Chen, F. 2021 Powerful tools for productivity improvements in microalgal production. Renew. Sust. Energ. Rev., 152, 111609 (article ID).
Keywords: Microalgal production; Productivity improvement; Kinetic model; Metabolic flux analysis; Genetic tool; Lipid biosynthesis
Strain(s): 144,  2140,  2146 
DOI: 10.1016/j.rser.2021.111609

Liu, Z., Hou, Y., He, C., Wang, X., Chen, S., Huang, Z., Chen, F. 2020 Enhancement of linoleic acid content stimulates astaxanthin esterification in Coelastrum sp. Bioresour. Technol., 300, 122649 (article ID).
Keywords: Linoleic acid; astaxanthin esterification; Coelastrum sp.; Free astaxanthin; Fatty acid profile
Strain(s): 144 
PubMed: 31896045
DOI: 10.1016/j.biortech.2019.122649

Praveenkumar, R., Lee, J., Vijaya, D., Lee, S. Y., Lee, K., Sim, S. J., Hong, M. E., Kim, Y.-E., Oh, Y.-K. 2020 Morphological change and cell disruption of Haematococcus pluvialis cyst during high-pressure homogenization for astaxanthin recovery. Appl. Sci., 10, 513 (article ID).
Keywords: Haematococcus pluvialis; high-pressure homogenization; astaxanthin; cyst; cell disruption
Strain(s): 144 
DOI: 10.3390/app10020513

Butler, T. & Golan, Y. 2020 Astaxanthin production from microalgae. In Microalgae biotechnology for food, health and high value products, Eds. by Alam, Md. A., Xu, J-L., Wang, Z., Springer, Singapore, pp. 175-242.
Keywords: Astaxanthin; Contamination; Biomass; Bioreactors; Extraction; H. pluvialis
Strain(s): 144 
DOI: 10.1007/978-981-15-0169-2_6

Azizi, M., Moteshafi, H., Hashemi, M. 2020 Distinctive nutrient designs using statistical approach coupled with light feeding strategy to improve the Haematococcus pluvialis growth performance and astaxanthin accumulation. Bioresour. Technol., 300, 122594 (article ID).
Keywords: H. pluvialis; Astaxanthin; Nutrients designing; Optimization; Light-feeding strategy
Strain(s): 144 
PubMed: 31901774
DOI: 10.1016/j.biortech.2019.122594

Lu, Z., Dai, J., Zheng, L., Teng, Z., Zhang, Q., Qiu, D., Song, L. 2020 Disodium 2-oxoglutarate promotes carbon flux into astaxanthin and fatty acid biosynthesis pathways in Haematococcus. Bioresour. Technol., 299, 122612 (article ID).
Keywords: Haematococcus pluvialis; Disodium 2-oxoglutarate; Astaxanthin production; Fatty acids biosynthesis; Carbon allocation
Strain(s): 144 
PubMed: 31874452
DOI: 10.1016/j.biortech.2019.122612

Widyaningrum, D. & Ohama, T. 2020 Initial study of polymer-based nanoparticles effect on carotenogenesis of Haematococcus lacustris. In IOP Conference Series: Earth and Environmental Science, IOP Publishing Ltd, 457, 012035 (article ID).
Keywords: Astaxanthin; carotenogenesis; Haematococcus lacustris; isobutyl-cyanoacrylate; nanoparticles
Strain(s): 144 
DOI: 10.1088/1755-1315/457/1/012035

Kim, Y. E., Matter, I. A., Lee, N., Jung, M., Lee, Y. C., Choi, S. A., Lee, S. Y., Kim, J. R., Oh, Y. K. 2020 Enhancement of astaxanthin production by Haematococcus pluvialis using magnesium aminoclay nanoparticles. Bioresour. Technol., 307, 123270 (article ID).
Keywords: Haematococcus pluvialis; Astaxanthin; Nanoparticle; Aminoclay; Lipid
Strain(s): 144 
PubMed: 32253126
DOI: 10.1016/j.biortech.2020.123270

Han, S.-I., Chang, S. H., Lee, C., Jeon, M. S., Heo, Y. M., Kim, S. 2020 Astaxanthin biosynthesis promotion with pH shock in the green microalga, Haematococcus lacustris. Bioresour. Technol., 314, 123725 (article ID).
Keywords: Haematococcus lacustris; Astaxanthin; pH shock; Biological change; Mass culture
Strain(s): 144 
PubMed: 32615445
DOI: 10.1016/j.biortech.2020.123725

Azizi, M., Moteshafi, H., Hashemi, M. 2020 A novel CO2 steady feeding based on the pH steady strategy data in the Haematococcus pluvialis cultivation to maximize the cell growth and carbon bio-sequestration. Bioresour. Technol., 314, 123752 (article ID).
Keywords: Haematococcus pluvialis; CO2 feeding; Productivity; CO2 bio-fixation; RuBisCO activity
Strain(s): 144 
PubMed: 32629377
DOI: 10.1016/j.biortech.2020.123752

Tharek, A., Jamaluddin, H., Salleh, M. M., Yahya, N. A., Kaha, M., Hara, H., Iwamoto, K., Mohamad, S. E. 2020 Astaxanthin production by tropical microalgae strains isolated from environment in Malaysia. Asian Jr. of Microbiol. Biotech. Env. Sc., 22, 168-173.
Keywords: Astaxanthin, H. pluvialis; Coelastrum sp.; Acutodesmus obliquus; High light; Nitrogen starvation; mixotrophy
Strain(s): 144 

Morimoto, D., Yoshida, T., Sawayama, S. 2020 Draft genome sequence of the astaxanthin-producing microalga Haematococcus lacustris Strain NIES-144. Microbiol. Resour. Ann.., 9, e00128-20 (article ID).
Strain(s): 144 
PubMed: 32499361
DOI: 10.1128/MRA.00128-20

Lu, Z., Zheng, L., Liu, J., Dai, J., Song, L. 2019 A novel fed-batch strategy to boost cyst cells production based on the understanding of intracellular carbon and nitrogen metabolism in Haematococcus pluvialis. Bioresour Technol., 289, 121744 (article ID).
Keywords: Haematococcus pluvialis; C/N metabolism; Astaxanthin biosynthesis; Series-gradient-fed strategy; Hyper-production
Strain(s): 144 
PubMed: 31323718
DOI: 10.1016/j.biortech.2019.121744

Widyaningrum, D., Iida, D., Tanabe, Y., Hayashi, Y., Kurniasih, S. D., Ohama, T. 2019 Acutely induced cell mortality in the unicellular green alga Chlamydomonas reinhardtii (Chlorophyceae) following exposure to acrylic resin nanoparticles. J. Phycol., 55, 118-133.
Keywords: abnormal swimming behavior; cell mortality; cell wall damage; Chlamydomonas rein-hardtii; poly(isobutyl-cyanoacrylate) nanoparticles; ROS
Strain(s): 35,  144,  362,  418,  421,  432,  438,  456,  545,  571,  732,  737,  858,  1022,  1048,  1848,  2150,  2169,  2201,  2202,  2208,  2209,  2212,  2280,  2352,  2462,  2578 
PubMed: 30304548
DOI: 10.1111/jpy.12798

Choi, H. I., Lee, J. S., Choi, J. W., Shin, Y. S., Sung, Y. J., Hong, M. E., Kwak, H. S., Kim, C. Y., Sim, S. J. 2019 Performance and potential appraisal of various microalgae as direct combustion fuel. Bioresour. Technol., 273, 341-349.
Keywords: Microalgae; Solid fuel; Direct combustion; The holistic analyses; Negative emissions
Strain(s): 144 
PubMed: 30448687
DOI: 10.1016/j.biortech.2018.11.030

Hiramatsu, K., Ideguchi, T., Yonamine, Y., Lee, S. W., Luo, Y., Hashimoto, K., Ito, T., Hase, M., Park, J.-W., Kasai, Y., Sakuma, S., Hayakawa, T., Arai, F., Hoshino, Y., Goda, K. 2019 High-throughput label-free molecular fingerprinting flow cytometry. Sci. Adv., 5, eaau0241 (article ID).
Strain(s): 48,  144,  4141 
PubMed: 30746443
DOI: 10.1126/sciadv.aau0241

Yokono, M., Takabayashi, A., Kishimoto, J., Fujita, T., Iwai, M., Murakami, A., Akimoto, S., Tanaka, A. 2019 The PSI-PSII megacomplex in green plants. Plant Cell Physiol., 60, 1098–1108.
Keywords: Energy transfer; Nonphotochemical quenching; Photosystem
Strain(s): 144,  296,  303,  2285,  2541 
PubMed: 30753722
DOI: 10.1093/pcp/pcz026

Hwang, S. W., Choi, H. I., Sim, S. J. 2019 Acidic cultivation of Haematococcus pluvialis for improved astaxanthin production in the presence of a lethal fungus. Bioresour. Technol., 278, 138-144.
Keywords: Haematococcus pluvialis; Paraphysoderma sedebokerensis; Acidic cultivation; Stress relief; Astaxant
Strain(s): 144 
PubMed: 30685617
DOI: 10.1016/j.biortech.2019.01.080

Han, J.-I., Yao, J., Lee, C., Park, J., Choi, Y.-E. 2019 A novel approach to enhance astaxanthin production in Haematococcus lacustris using a microstructure-based culture platform. Algal Res., 39, 101464.
Keywords: Haematococcus lacustris; Microfabricated structure; Astaxanthin; ROS; Mechanical stimulation
Strain(s): 144 
DOI: 10.1016/j.algal.2019.101464

Lee, C., Jeon, M., Kim, J. Y., Lee, S. H., Kim, D. G., Roh, S. W., Choi, Y.-E. 2019 Effects of an auxin-producing symbiotic bacterium on cell growth of themicroalgaHaematococcus pluvialis: Elevation of cell density andprolongation of exponential stage. Algal Res., 41, 101547.
Keywords: Unicellular microalgae; Haematococcus spp.; Symbiotic bacteria; Achromobactersp.; Growth promotion; Auxin
Strain(s): 144 
DOI: 10.1016/j.algal.2019.101547

Yoshitomi, T., Shimada, N., Iijima, K., Hashizume, M., Yoshimoto, K. 2019 Polyethyleneimine-induced astaxanthin accumulation in the green alga Haematococcus pluvialis by increased oxidative stress. J. Biosci. Bioeng., 128, 751-754.
Keywords: Polyethyleneimine; Haematococcus pluvialis; Astaxanthin; Cellular uptake; Reactive oxygen species; Flocculant; Oxidative stress; Microalgae
Strain(s): 144 
PubMed: 31253510
DOI: 10.1016/j.jbiosc.2019.06.002

Irshad, M., Myint, A. A., Hong, M. E., Kim, J., Sim, S. J. 2019 One-pot, simultaneous cell wall disruption and complete extraction of astaxanthin from Haematococcus pluvialis at room temperature. ACS Sustain. Chem. Eng., 7, 13898-13910.
Keywords: Haematococcus pluvialis; One-pot method; Cell wall disruption; Extraction; Astaxanthin; Antioxidant activity; GRAS solvent
Strain(s): 144 
DOI: 10.1021/acssuschemeng.9b02089

Zhu, J. & Wakisaka, M. 2019 Effect of air nanobubble water on the growth and metabolism of Haematococcus lacustris and Botryococcus braunii. J. Nutr. Sci. Vitaminol., 65, S212-S216.
Keywords: Botryococcus braunii; Haematococcus lacustris; astaxanthin; lipid; nanobubble water
Strain(s): 144,  2199 
PubMed: 31619633
DOI: 10.3177/jnsv.65.S212

Khoo, K. S., Lee, S. Y., Ooi, C. W., Fu, X., Miao, X., Ling, T. C., Show, P. L. 2019 Recent advances in biorefinery of astaxanthin from Haematococcus pluvialis. Bioresour. Technol., 288, 121606 (article ID).
Keywords: Astaxanthin; Haematococcus pluvialis; Cultivation; Pretreatment; Biorefinery
Strain(s): 144 
PubMed: 31178260
DOI: 10.1016/j.biortech.2019.121606

Choi, YY., Hong, ME., Jin, ES., Woo, HM., Sim, SJ 2018 Improvement in modular scalability of polymeric thin-film photobioreactor for autotrophic culturing of Haematococcus pluvialis using industrial flue gas. Bioresour. Technol., 249, 519-526.
Keywords: Haematococcus pluvialis; Autotrophic; Bubble column photobioreactor; Scale-up; Hydrodynamic property
Strain(s): 144 
PubMed: 29078178
DOI: 10.1016/j.biortech.2017.10.060

Zhang, C., Chen, G., Wang, Y., Guo, C., Zhou, J. 2018 Physiological and molecular responses of Prorocentrum donghaiense to dissolved inorganic phosphorus limitation. Mar. Pollut. Bull., 129, 562-572.
Keywords: Prorocentrum donghaiense; Dissolved inorganic phosphorus; Limitation; Suppression subtractive hybridization; Molecular response
Strain(s): 144 
PubMed: 29055559
DOI: 10.1016/j.marpolbul.2017.10.031

Lee, C., Jeon, M. S., Vo, T-T., Park, C., Choi, J-S., Kwon, J., Roh, S. W., Choi, Y-E. 2018 Establishment of a new strategy against Microcystis bloom using newly isolated lytic and toxin-degrading bacteria. J. Appl. Phycol., 30 1795–1806.
Keywords: Algal bloom; Cyanobacterium; Bacterial isolation; Microcystis; Biological control; Microcystin degradation
Strain(s): 144 
DOI: 10.1007/s10811-018-1403-8

Sun, P., Cheng, K-W., He, Y., Liu, B., Mao, X., Chen, F. 2018 Screening and identification of inhibitors of advanced glycation endproduct formation from microalgal extracts. Food Funct., 9, 1683-1691.
Strain(s): 144 
PubMed: 29473927
DOI: 10.1039/C7FO01840A

Hong, M. E.1, Choi, H. I., Kwak, H. S., Hwang, S. W., Sung, Y. J., Chang, W. S., Sim, S. J. 2018 Rapid selection of astaxanthin-hyperproducing Haematococcus mutant via azide-based colorimetric assay combined with oil-based astaxanthin extraction. Bioresour. Technol., 267, 175-181.
Keywords: Haematococcus pluvialis; Autotrophic astaxanthin production; High-throughput screening; Azide-based colorimetric assay; Oil-based astaxanthin extraction method
Strain(s): 144 
PubMed: 30014996
DOI: 10.1016/j.biortech.2018.07.033

Sheng, B., Fan, F., Huang, J. K., Bai, W. M., Wang, J., Li, S. L., Li, W., Wan, M. X., Li, Y. G. 2018 Investigation on models for light distribution of Haematococcus pluvialis during astaxanthin accumulation stage with an application case. Algal Res., 33, 182-189.
Keywords: Light attenuation model; Haematococcus pluvialis; CFD;Induction experiment
Strain(s): 144 
DOI: 10.1016/j.algal.2018.05.011

Lee, C., Ahn, J.-W., Kim, J.-B., Kim, J. Y., Choi, Y.-E. 2018 Comparative transcriptome analysis of Haematococcus pluvialis on astaxanthin biosynthesis in response to irradiation with red or blue LED wavelength. World J. Microbiol. Biotechnol., 34, 96 (article ID).
Keywords: Gene expression; Carotenoid biosynthesis; Differentially expressed genes; Microalgae; LED wavelength
Strain(s): 144 
PubMed: 29916185
DOI: 10.1007/s11274-018-2459-y

Nagarajan, D., Lee, D.-J., Chang, J. 2018 Heterotrophic microalgal cultivation. In Bioreactors for microbial biomass and energy conversion, Eds. by Liao Q., Chang J., Herrmann C., Xia A., Springer, Singapore, pp. 117-160.
Strain(s): 144,  227,  2280 
DOI: 10.1007/978-981-10-7677-0_4

Allewaert, C. C., Vanormelingen, P., Daveloose, I., Vyverman, T. 2017 Intraspecific trait variation affecting astaxanthin productivity in two Haematococcus (Chlorophyceae) species. Algal Res., 21, 191-202.
Keywords: Astaxanthin productivity; Haematococcus pluvialis; Haematococcus rubicundus; Functional traits; Common-garden experiment; Intraspecific variation
Strain(s): 144 
DOI: 10.1016/j.algal.2016.10.021

Kiperstok, A. C., Sebestyén, P., Podola, B., Melkonian, M. 2017 Biofilm cultivation of Haematococcus pluvialis enables a highly productive one-phase process for astaxanthin production using high light intensities. Algal Res., 21, 213-222.
Keywords: Microalgae; Immobilized cultivation; Irradiation; Carbon dioxide; Twin-Layer; Carotenoid
Strain(s): 144 
DOI: 10.1016/j.algal.2016.10.025

Choi, Y. Y., Joun, J. M., Lee, J., Hong, M. E., Pham, H., Chang, W. S., Sim, S. J. 2017 Development of large-scale and economic pH control system for outdoor cultivation of microalgae Haematococcus pluvialis using industrial flue. Bioresour. Technol., 244, 1235-1244.
Keywords: Haematococcus pluvialis; Astaxanthin; Polymeric thin-film photobioreactor; Autotrophic buffer system; Flue gas
Strain(s): 144 
PubMed: 28647321
DOI: 10.1016/j.biortech.2017.05.147

Hong, M.-E., Choi, Y. Y., Sim, S. J. 2016 Effect of red cyst cell inoculation and iron (II) supplementation on autotrophic astaxanthin production by Haematococcus pluvialis under outdoor summer conditions. J. Biotechnol., 218, 25–33.
Keywords: Haematococcus pluvialis; Photoautotrophic culture; Astaxanthin; Summer outdoor conditions; Red cyst cell (aplanospore) inoculation method; Iron(Fe2+) supplementation method
Strain(s): 144 
PubMed: 26630998
DOI: 10.1016/j.jbiotec.2015.11.019

Zhang, Z., Wang, B., Hu, Q., Sommerfeld, M., Li, Y., Han, D. 2016 A new paradigm for producing astaxanthin from the unicellular green alga Haematococcus pluvialis. Biotech. Bioeng., 113, 2088-2099.
Keywords: astaxanthin; Haematococcus pluvialis; heterotrophy; acclimation
Strain(s): 144 
PubMed: 27563850
DOI: 10.1002/bit.25976

Munakata, H., Nakada, T., Nakahigashi, K., Nozaki, H., Tomita, M. 2016 Phylogenetic position and molecular chronology of a colonial green flagellate, Stephanosphaera pluvialis (Volvocales, Chlorophyceae), among unicellular algae. J. Eucaryot. Microbiol., 63, 340-348.
Keywords: Balticola; coloniality; divergence time; evolution; molecular phylogeny
Strain(s): 123,  144,  421,  428,  432,  439,  446,  567,  569,  571,  656,  861,  887,  968,  1048,  2293,  2564,  4124,  4125 
PubMed: 26595722
DOI: 10.1111/jeu.12283

Lee, T. Y., Praveenkumar, R., Oh, Y. K. Lee, K., Kim, S. H. 2016 Alginate microgels created by selective coalescence between core drops paired with an ultrathin shell. J. Mater. Chem. B, 4, 3232-3238.
Strain(s): 144 
DOI: 10.1039/c6tb00580b

Poonkum, W., Powtongsook, S., Pavasant, P. 2015 Astaxanthin induction in microalga H. pluvialis with flat panel airlift photobioreactors under indoor and outdoor conditions. Prep. Biochem. Biotechnol., 45, 1-17.
Keywords: carotenoid; Haematococcus pluvialis; mature cyst; microalgae; pigment; scale-up
Strain(s): 144 
PubMed: 25105532
DOI: 10.1080/10826068.2013.867871

Wen, Z., Liu, Z., Hou, Y., Liu, C., Gao, F., Zheng, Y., Chen, F. 2015 Ethanol induced astaxanthin accumulation and transcriptional expression of carotenogenic genes in Haematococcus pluvialis. Enzyme Microb. Technol., 78, 10-17.
Keywords: Haematococcus pluvialis; Astaxanthin; Ethanol; ipi; Fed-batch induction
Strain(s): 144 
PubMed: 26215339
DOI: 10.1016/j.enzmictec.2015.06.010

Giannelli, L., Yamada, H., Katsuda, T., Yamaji, H. 2015 Effects of temperature on the astaxanthin productivity and light harvesting characteristics of the green alga Haematococcus pluvialis. J. Biosci. Bioeng., 119, 345–350.
Keywords: Haematococcus pluvialis; Photobioreactor; Astaxanthin; Photosynthetic efficiency
Strain(s): 144 
PubMed: 25441445
DOI: 10.1016/j.jbiosc.2014.09.002

Kwak, H. S., Kim, J. Y. H., Sim, S. J. 2015 A microreactor system for cultivation of Haematococcus pluvialis and astaxanthin production. J. Nanosci. Nanotechnol., 15, 1618-1623.
Keywords: Astaxanthin; Haematococcus pluvialis; Microfluidic Devices; Nile Red; PDMS
Strain(s): 144 
PubMed: 26353702
DOI: 10.1166/jnn.2015.9321

Giannelli, L., Yamaji, H., Katsuda, T. 2015 A numerical model for the quantification of light/dark cycles in microalgal cultures: Air-lift and bubble-column photobioreactor analysis by means of computational fluid dynamics. J. Chem. Eng. Jpn., 48, 61-71.
Keywords: Microalgae; Photobioreactor; Computational Fluid Dynamics; Flashing Light; Light Conversion Efficiency
Strain(s): 144 
DOI: 10.1252/jcej.14we093

Wan, M., Hou, D., Li, Y., Fan, J., Huang, J., Liang, S., Wang, W., Pan, R., Wang, J., Li, S. 2014 The effective photoinduction of Haematococcus pluvialis for accumulating astaxanthin with attached cultivation. Bioresour. Technol., 163, 26-32.
Keywords: Haematococcus pluvialis; Astaxanthin; Biomass; Attached cultivation; Photoinduction
Strain(s): 144 
PubMed: 24787315
DOI: 10.1016/j.biortech.2014.04.017

Su, Y., Wang, J., Shi, M., Niu, X., Yu, X., Gao, L., Zhang, X., Chen, L., Zhang, W. 2014 Metabolomic and network analysis of astaxanthin-producing Haematococcus pluvialis under various stress conditions. Bioresour. Technol., 170, 522-529.
Keywords: Astaxanthin; Stress; Metabolomics; Metabolic network; Haematococcus pluvialis
Strain(s): 144 
PubMed: 25164345
DOI: 10.1016/j.biortech.2014.08.018

Liu, J., Gerken, H., Li, Y. 2014 Single-tube colony PCR for DNA amplification and transformant screening of oleaginous microalgae. J. Appl. Microbiol., 26, 1719-1726.
Keywords: Biofuels; Colony PCR; High throughput; Microalgae; Single tube; Transformant screening
Strain(s): 144 
DOI: 10.1007/s10811-013-0220-3

Yoo, J. J., Choi, S. P., Kim, J. Y. H., Chang, W. S., Sim, S. J. 2013 Development of thin-film photo-bioreactor and its application to outdoor culture of microalgae. Bioprocess. Biosyst. Eng., 36, 729-736.
Keywords: Photo-bioreactor; Microalgae; Haematococcus pluvialis; Scale-up; Outdoor
Strain(s): 144 
PubMed: 23361185
DOI: 10.1007/s00449-013-0898-2

Zhang, L., Fan, Y., Shi, F., Qin, S., Liu, B. 2012 Molecular cloning, characterization, and expression analysis of a cytosolic HSP90 gene from Haematococcus pluvialis. J. Appl. Phycol., 24, 1601-1612.
Keywords: Haematococcus pluvialis; Heat shock protein 90; cDNA cloning; qRT-PCR; mRNA expression
Strain(s): 144 
DOI: 10.1007/s10811-012-9821-5

Yoo, J. J., Choi, S. P., Kim, B. W., Sim, S. J. 2012 Optimal design of scalable photo-bioreactor for phototropic culturing of Haematococcus pluvialis. Bioprocess. Biosyst. Eng., 35, 309-315.
Keywords: Photo-bioreactor; Haematococcus pluvialis; Astaxanthin; Improved factors; Mixing
Strain(s): 144 
PubMed: 21909667
DOI: 10.1007/s00449-011-0616-x

Hong, M. E., Choi, S. P., Park, Y. I., Kim, Y. K., Chang, W. S., Kim, B. W., Sim, S. J. 2012 Astaxanthin production by a highly photosensitive Haematococcus mutant. Process Biochem., 47, 1972–1979.
Keywords: Haematococcus pluvialis; Astaxanthin; Photo-inducible mutant; Photo-sensitivity
Strain(s): 144 
DOI: 10.1016/j.procbio.2012.07.007

Takaichi, S. 2011 Carotenoids in algae: distributions, biosyntheses and functions. Mar. Drugs, 9, 1101-1118.
Keywords: algal phylogeny; biosynthesis of carotenoids; distribution of carotenoids; function of carotenoids; pigment-protein complex
Strain(s): 144,  1332,  3377 
PubMed: 21747749
DOI: 10.3390/md9061101

Issarapayup, K., Powtongsook, S., Pavasant, P. 2011 Economical review of Haematococcus pluvialis culture in flat-panel airlift photobioreactors. Aquac. Eng., 44, 65-71.
Keywords: Airlift photobioreactor; Microalga; Economical analysis; Bioprocess design
Strain(s): 144 
DOI: 10.1016/j.aquaeng.2011.03.002

Kunugi, M., Matsumoto, M., Kondo, K. 2010 Effect of culture conditions on production of useful materials by Haematococcus pluvialis. Bull. Soc. Sea Water Sci., Jpn, 64, 297-304 (in Japanese with English summary).
Keywords: biomass; microalgae; carbon dioxide; useful material production
Strain(s): 144 

Wu, Z.Y., Chen, G.Q., Chong, S.K., Mak, N.-K., Chen, F., Jiang, Y. 2010 Ultraviolet-B radiation improves astaxanthin accumulation in green microalga Haematococcus pluvialis. Biotechnol. Lett., 32, 1911-1914.
Keywords: Antioxidant enzyme; Astaxanthin; Haematococcus pluvialis; Ultraviolet-B radiation
Strain(s): 144 
PubMed: 20697930
DOI: 10.1007/s10529-010-0371-0

Issarapayup, K., Powtongsook, S., Pavasant, P. 2009 Flat panel airlift photobioreactors for cultivation of vegetative cells of microalga Haematococcus pluvialis. J. Biotechnol., 142, 227-232.
Keywords: airlift photobioreactor; vegetative cells; astaxanthin; bioprocess design; microalga
Strain(s): 144 
PubMed: 19422861
DOI: 10.1016/j.jbiotec.2009.04.014

Katsuda, T., Shiraishi, H., Ishizu, N., Ranjbar, R., Katoh, S. 2008 Effect of light intensity and frequency of flashing light from blue light emitting diodes on astaxanthin production by Haematococcus pluvialis. J. Biosci. Bioeng., 105, 216-220.
Keywords: flashing light; blue light emitting diode; light intensity; astaxanthin; Haematococcus pluvialis
Strain(s): 144 
PubMed: 18397771
DOI: 10.1263/jbb.105.216

Ranjbar, R., Inoue, R., Katsuda, T., Yamaji, H., Katoh, S. 2008 High efficiency production of astaxanthin in an airlift photobioreactor. J. Biosci. Bioeng., 106, 204-207.
Keywords: Haematococcus pluvialis; airlift bubble column; liquid circulation;nirate concentration; astaxanthin
Strain(s): 144 
PubMed: 18804066
DOI: 10.1263/jbb.106.204

Ranjbar, R., Inoue, R., Shiraishi, H., Katsuda, T., Katoh, S. 2008 High efficiency production of astaxanthin by autotrophic cultivation of Haematococcus pluvialis in a bubble column photobioreactor. Biochem. Eng. J., 39, 575-580.
Keywords: Haematococcus pluvialis; autotrophic culture; bubble column; Fed-batch; nitrate concentration astaxanthin
Strain(s): 144 
DOI: 10.1016/j.bej.2007.11.010

Hu, ZY., Li, YT., Sommerfeld, M., Chen, F., Hu, Q. 2008 Enhanced protection against oxidative stress in an astaxanthin-overproduction Haematococcus mutant (Chlorophyceae). Eur. J. Phycol., 43, 365-376.
Keywords: astaxanthin; carotenogenesis; flow cytometry; Haematococcus pluvialis; oxidative stress; pigment mutant
Strain(s): 144 
DOI: 10.1080/09670260802227736

Kang, C.-D., Sim, S.-J. 2008 Direct extraction of astaxanthin from Haematococcus culture using vegetable oils. Biotechnol. Lett., 30, 441–444.
Keywords: Astaxanthin; Direct extraction; Green process; Haematococcus pluvialis; Vegetable oil
Strain(s): 144 
PubMed: 17972016
DOI: 10.1007/s10529-007-9578-0

Shimonaga, T., Konishi, M., Oyama, Y., Fujiwara, S., Satoh, A., Fujita, N., Colleoni, C., Buléon, A., Putaux, J.-L., Ball, S. G., Yokoyma, A., Hara, Y., Nakamura, Y., Tsuzuki, M. 2008 Variation in Storage α-polyglucans of the Porphyridiales (Rhodophyta). Plant Cell Physiol., 49, 103-116.
Keywords: Amylose; Floridean starch; Glycogen; Porphyridiales; Rhodophyta; Semi-amylopection
Strain(s): 18,  144,  250,  530,  551,  2138,  2160,  2258,  2280 
PubMed: 18079144
DOI: 10.1093/pcp/pcm172

Grewe, C., Griehl, C. 2008 Time- and media-dependent secondary carotenoid accumulation in Haematococcus pluvialis. Biotechnol. J., 3, 1232-1244.
Keywords: Astaxanthin; Carotenoid biosynthesis; ; Haematococcus pluvialis; LC-MS; Media
Strain(s): 144 
PubMed: 18683169
DOI: 10.1002/biot.200800067

Domínguez-Bocanegra, A. R., Ponce-Noyola, T., Torres-Muñoz, J. A. 2007 Astaxanthin production by Phaffia rhodozyma and Haematococcus pluvialis: a comparative study. Appl. Microbiol. Biotechnol., 75, 783-791.
Keywords: Haematococcus pluvialis; Phaffia rhodozyma; Astaxanthin synthesis; Coconut milk
Strain(s): 144 
PubMed: 17333170
DOI: 10.1007/s00253-007-0889-9

Kaewpintong, K., Shotipruk, A., Powtongsook, S., Pavasant, P. 2007 Photoautotrophic high-density cultivation of vegetative cells of Haematococcus pluvialis in airlift bioreactor. Bioresour. Technol., 98, 288-295.
Keywords: Airlift bioreactors; Astaxanthin; Autotrophic; Bioprocess design; Bubble columns; Microalgae
Strain(s): 144 
PubMed: 16516464
DOI: 10.1016/j.biortech.2006.01.011

Katsuda, T., Shimahara, K., Shiraishi, H., Yamagami, K., Ranjbar, R., Katoh, S. 2006 Effect of flashing light from blue light emitting diodes on cell growth and astaxanthin production of Haematococcus pluvialis. J. Biosci. Bioeng., 102, 442-446.
Keywords: flashing light; blue light emitting diode; astaxanthin; Haematococcus pluvialis
Strain(s): 144 
PubMed: 17189172
DOI: 10.1263/jbb.102.442

Yamamoto, H., Hada, K., Yamaji, H., Katsuda, T., Ohno, H., Fukuda, H. 2006 Application of regularized alternating least squares and independent component analysis to HPLC-DAD data of Haematococcus pluvialis metabolites. Biochem. Eng. J., 32, 149-156.
Keywords: metabolomics; chemometrics; HPLC-DAD; alternating least squares; regularized term; independent component analysis
Strain(s): 144 
DOI: 10.1016/j.bej.2006.09.014

Yoshimura, S., Ranjbar, R., Inoue, R., Katsuda, T., Katoh, S. 2006 Effective utilization of transmitted light for astaxanthin production by Haematococcus pluvialis. J. Biosci. Bioeng., 102, 97-101.
Keywords: astaxanthin; Haematococcus pluvialis; transmitted light; physiological response
Strain(s): 144 
PubMed: 17027870
DOI: 10.1263/jbb.102.97

Steinbrenner, J. & Sandmann, G. 2006 Transformation of the green alga Haematococcus pluvialis with a phytoene desaturase for accelerated astaxanthin biosynthesis. Appl. Environ. Microbiol., 72, 7477-7484.
Strain(s): 144 
PubMed: 17012596
DOI: 10.1128/AEM.01461-06

Lababpour, A., Shimahara, K., Hada, K., Kyoui, Y., Katsuda, T., Katoh, S. 2005 Fed-batch culture under illumination with blue light emitting diodes (LEDs) for astaxanthin production by Haematococcus pluvialis. J. Biosci. Bioeng., 100, 339-342.
Keywords: astaxanthin; Haematococcus pluvialis; fed-batch culture; blue light emitting diode (LED)
Strain(s): 144 
PubMed: 16243287
DOI: 10.1263/jbb.100.339

Kang, C. D., Lee, J. S., Park, T. H., Sim, S. J. 2005 Comparison of heterotrophic and photoautotrophic induction on astaxanthin production by Haematococcus pluvialis. Appl. Microbiol. Biotechnol., 68, 237-241.
Strain(s): 144 
PubMed: 15711942
DOI: 10.1007/s00253-005-1889-2

Katsuda, T., Lababpour, A., Shimahara, K., Katoh, S. 2004 Astaxanthin production by Haematococcus pluvialis under illumination with LEDs. Enzyme Microb. Technol., 35, 81-86.
Keywords: astaxanthin; light emitting diode; wavelength; accumulation of astaxanthin
Strain(s): 144 
DOI: 10.1016/j.enzmictec.2004.03.016

Lababpour, A., Hada, K., Shimahara, K., Katsuda, T., Katoh, S. 2004 Effects of nutrient supply methods and illumination with blue light emitting diodes (LEDs) on astaxanthin production by Haematococcus pluvialis. J. Biosci. Bioeng., 98, 452-456.
Keywords: astaxanthin; Haematococcus pluvialis; blue light emitting diode (LED); nutrient supply
Strain(s): 144 
PubMed: 16233735
DOI: 10.1016/S1389-1723(05)00311-7

Domínguez-Bocanegra, A. R., Legarreta, I. G., Jeronimo, F. M. 2004 Influence of environmental and nutritional factors in the production of astaxanthin from Haematococcus pluvialis. Bioresour. Technol., 92, 209-214.
Keywords: Haematococcus; Astaxanthin production; Light intensity; Aeration
Strain(s): 144 
PubMed: 14693455
DOI: 10.1016/j.biortech.2003.04.001

Steinbrenner, J. & Linden, H. 2003 Light induction of carotenoid biosynthesis genes in the green alga Haematococcus pluvialis: regulation by photosynthetic redox control. Plant Mol. Biol., 52, 343-356.
Keywords: astaxanthin; carotenoid biosynthesis; green algae; Haematococcus pluvialis; lycopene βcyclase; redox regulation
Strain(s): 144 
PubMed: 12856941
DOI: 10.1023/A:1023948929665

Mori, F., Erata, M., Watanabe, M. M. 2002 Cryopreservation of cyanobacteria and green algae in the NIES-Collection. Microbiol. Cult. Coll., 18, 45-55.
Keywords: cryopreservation; cyanobacteria; green algae; FDA staining method; NIES-Collection
Strain(s): 19,  21,  22,  23,  24,  25,  26,  27,  28,  29,  30,  31,  32,  33,  34,  35,  36,  37,  38,  39,  40,  41,  44,  45,  46,  50,  51,  52,  53,  54,  55,  56,  58,  59,  60,  61,  62,  63,  64,  65,  66,  67,  68,  69,  70,  73,  74,  75,  76,  77,  78,  79,  80,  81,  87,  89,  90,  91,  92,  93,  94,  95,  96,  97,  98,  99,  100,  101,  102,  103,  104,  105,  106,  107,  108,  109,  110,  111,  112,  119,  120,  122,  123,  125,  127,  128,  129,  130,  131,  132,  133,  134,  135,  137,  138,  139,  144,  147,  151,  152,  153,  154,  155,  156,  157,  158,  159,  160,  162,  163,  164,  165,  166,  167,  168,  170,  171,  172,  173,  174,  175,  176,  177,  178,  179,  180,  181,  182,  183,  185,  186,  187,  188,  189,  191,  192,  193,  194,  197,  198,  199,  200,  201,  202,  203,  204,  205,  206,  207,  208,  209,  210,  211,  212,  213,  214,  215,  216,  217,  224,  226,  227,  228,  229,  230,  231,  232,  241,  242,  243,  244,  245,  246,  248,  257,  259,  261,  262,  263,  266,  267,  268,  287,  288,  289,  290,  294,  295,  297,  298,  299,  300,  301,  302,  303,  305,  306,  308,  309,  310,  312,  313,  329,  334,  337,  338,  339,  340,  341,  342,  349,  351,  359,  360,  361,  362,  375,  378,  379,  380,  382,  384,  385,  390,  394,  396,  397,  398,  415,  416,  418,  419,  421,  422,  423,  424,  425,  426,  427,  428,  429,  430,  431,  432,  433,  434,  436,  437,  438,  439,  440,  446,  447,  448,  449,  450,  451,  452,  453,  454,  455,  456,  457,  458,  459,  460,  464,  468,  469,  474,  478,  479,  480,  481,  503,  504,  505,  506,  507,  509,  510,  512,  514,  515,  522,  523,  524,  527,  528,  529,  530,  531,  532,  536,  537,  538,  539,  540,  541,  542,  543,  544,  545,  546,  564,  565,  566,  567,  568,  569,  570,  571,  572,  573,  574,  575,  576,  577,  578,  579,  580,  581,  582,  583,  584,  585,  592,  593,  594,  595,  596,  597,  598,  604,  610,  628,  630,  631,  632,  633,  634,  635,  636,  637,  638,  639,  640,  641,  642,  643,  644,  645,  646,  647,  648,  649,  650,  651,  652,  653,  654,  655,  656,  657,  658,  659,  660,  661,  662,  663,  664,  665,  666,  667,  672,  685,  686,  687,  688,  689,  690,  691,  692,  693,  694,  717,  718,  719,  720,  721,  722,  723,  724,  725,  726,  727,  728,  729 

Nozaki, H., Onishi, K., Morita, E. 2002 Differences in pyrenoid morphology are correlated with differences in the rbcL genes of members of the Chloromonas lineage (Volvocales, Chlorophyceae). J. Mol. Evol., 55, 414-430.
Keywords: ATP synthase β-subunit (atpB) gene; Chloromonas; gene evolution; large subunit of Rubisco (rbcL) gene; morphological evolution; P700 chlorophyll a-apoprotein A2 (psaB) gene; pyrenoid; Volvocales
Strain(s): 96,  123,  144,  213,  418,  421,  425,  428,  432,  439,  446,  447,  456,  474,  522,  564,  566,  567,  569,  571,  574,  582,  653,  732,  851,  858,  861,  875,  882,  883,  968 
PubMed: 12355262
DOI: 10.1007/s00239-002-2338-9

Steinbrenner, J. & Linden, H. 2001 Regulation of two carotenoid biosynthesis genes coding for phytoene synthase and carotenoid hydroxylase during stress-induced astaxanthin formation in the green alga Haematococcus pluvialis. Plant Physiol., 125, 810-817.
Strain(s): 144 
PubMed: 11161038
DOI: 10.1104/pp.125.2.810

Hata, N., Ogbonna, J. C., Hasegawa, Y., Taroda, H., Tanaka, H. 2001 Production of astaxanthin by Haematococcus pluvialis in a sequential heterotrophic-photoautotrophic culture. J. Appl. Phycol., 13, 395-402.
Keywords: astaxanthin; carotenoids; Haematococcus pluvialis; heterotrophic; photoautotrophic; two phase culture
Strain(s): 144 
DOI: 10.1023/A:1011921329568

Kobayashi, M. 2000 In vivo antioxidant role of astaxanthin under oxidative stress in the green alga Haematococcus pluvialis. Appl. Microbilo. Biotechnol., 54, 550-555.
Strain(s): 144 
PubMed: 11092631
DOI: 10.1007/s002530000

Kobayashi, M., Okada, T. 2000 Protective role of astaxanthin against u.v.-B irradiation in the green alga Haematococcus pluvialis. Biotechnol. Lett., 22, 177-181.
Keywords: antioxidant; astaxanthom; Haematococcus pluvialis oxidative stress; u.v.-B;
Strain(s): 144 
DOI: 10.1023/A:100564960983

Kobayashi, M., Todoroki, Y., Hirai, N., Kurimura, Y., Ohigashi, H., Tsuji, Y. 1998 Biological activities of abscisic acid analogs in the morphological change of the green alga Haematococcus pluvialis. J. Ferment. Bioeng., 85, 529-531.
Keywords: abscisic acid; astaxanthin; carotenogenesis; drought stress; encystment; plant hormone; Haematococcus pluvialis
Strain(s): 144 
DOI: 10.1016/S0922-338X(98)80076-7

Kobayashi, M., Hirai, N., Kurimura, Y., Ohigashi, H., Tsuji, Y. 1997 Abscisic acid-dependent algal morphogenesis in the unicellular green alga Haematococcus pluvialis. Plant Growth Regulation, 22, 79-85.
Keywords: abscisic acid; active oxygen; carotenoid; cyst formation; drought stress; Haematococcus pluvialis
Strain(s): 144 
DOI: 10.1023/A:1005862809711

Kobayashi, M., Kakizono, T., Nishio, N., Nagai, S., Kurimura, Y., Tsuji, Y. 1997 Antioxidant role of astaxanthin in the green alga Haematococcus pluvialis. Appl. Microbiol. Biotechnol., 48, 351-356.
Strain(s): 144 
DOI: 10.1007/s002530051

Kobayashi, M., Kurimura, Y., Kakizono, T., Nishio, N., Tsuji, Y. 1997 Morphological changes in the life cycle of the green alga Haematococcus pluvialis. J. Ferment. Bioeng., 84, 94-97.
Keywords: astaxanthin; encystment; germination; Haematococcus pluvialis; life cycle; maturation
Strain(s): 144 
DOI: 10.1016/S0922-338X(97)82794-8

Kobayashi, M., Kurimura, Y., Sakamoto, Y., Tsuji, Y. 1997 Selective extraction of astaxanthin and chlorophyll from the green alga Haematococcus pluvialis. Biotechnol. Tech., 11, 657-660.
Strain(s): 144 
DOI: 10.1023/A:1018455209445

Kobayashi, M., Kurimura, Y., Tsuji, Y. 1997 Light-independent, astaxanthin production by the green microalga Haematococcus pluvialis under salt stress. Biotechnol. Lett., 19, 507-509.
Strain(s): 144 
DOI: 10.1023/A:1018372900649

Chumpolkulwong, N., Kakizono, T., Ishii, H. 1997 Enzymatic conversion of b-carotene to astaxanthin by cell-extracts of a green alga Haematococcus pluvialis. Biotechnol. Lett., 19, 443-446.
Strain(s): 144 
DOI: 10.1023/A:1018392010218

Kajiwara, S., Kakizono, T., Saito, T., Kondo, K., Ohtani, T., Nishio, N., Nagai, S., Misawa, N. 1995 Isolation and functional identification of a novel cDNA for astaxanthin biosynthesis from Haematococcus pluvialis, and astaxanthin synthesis in Escherichia coli. Plant Mol. Biol., 29, 343-352.
Keywords: astaxanthin; canthaxanthin; carotenoid; xanthophyll; Haematococcus pluvialis; green alga
Strain(s): 144 
PubMed: 7579184
DOI: 10.1007/BF00043657

Tjahjono, A. E., Hayama, Y., Kakizono, T., Terada, Y., Nishio, N., Nagai, S. 1994 Hyper-accumulation of astaxanthin in a green alga Haematococcus pluvialis at elevated temperatures. Biotechnol. Lett., 16, 133-138.
Strain(s): 144 
DOI: 10.1007/BF01021659

Tjahjono, A. E., Kakizono, T., Hayama, Y., Nishio, N., Nagai S. 1994 Isolation of resistant mutants against carotenoid biosynthesis inhibitors for a green alga Haematococcus pluvialis, and their hybrid formation by protoplast fusion for breeding of higher astaxanthin producers. J. Ferment. Bioeng., 77, 352-357.
Strain(s): 144 
DOI: 10.1016/0922-338X(94)90003-5

Kobayashi, M., Kakizono, T., Nagai, S. 1993 Enhanced carotenoid biosynthesis by oxidative stress in acetate-induced cyst cells of a green unicellular alga, Haematococcus pluvialis. Appl. Environ. Microbiol., 59, 867-873.
Strain(s): 144 
PubMed: 16348895
DOI: 10.1128/AEM.59.3.867-873.1993

Kobayashi, M., Kakizono, T., Nagai, S. 1993 Photo-dependent astaxanthin biosynthesis in a green alga, Haematococcus pluvialis. Seibutsu-Kôgaku, 71, 233-237 (in Japanese with English summary).
Strain(s): 144 

Tjahjono, A. E., Kakizono, T., Hayama, Y., Nagai, S. 1993 Formation and regeneration of protoplast from a unicellular green alga Haematococcus pluvialis. J. Ferment. Bioeng., 75, 196-200.
Strain(s): 144 
DOI: 10.1016/0922-338X(93)90115-O

Kakizono, T., Kobayashi, M., Nagai, S. 1992 Effect of carbon/nitrogen ratio on encystment accompanied with astaxanthin formation in a green alga, Haematococcus pluvialis. J. Ferment. Bioeng., 74, 403-405.
Strain(s): 144 
DOI: 10.1016/0922-338X(92)90041-R

Kobayashi, M., Kakizono, T., Nishio, N., Nagai, S. 1992 Effects of light intensity, light quality, and illumination cycle on astaxanthin formation in a green alga, Haematococcus pluvialis. J. Ferment. Bioeng., 74, 61-63.
Strain(s): 144 
DOI: 10.1016/0922-338X(92)90271-U

Kobayashi, M., Kakizono, T., Yamaguchi, K., Nishio, N., Nagai, S. 1992 Growth and asta-xanthin formation of Haematococcus pluvialis in heterotrophic and mixotrophic conditions. J. Ferment. Bioeng., 74, 17-20.
Strain(s): 144 

Kobayashi, M., Kakizono, T., Nagai, S. 1991 Astaxanthin production by a green alga, Haematococcus pluvialis accompanied with morphological changes in acetate media. J. Ferment. Bioeng., 71, 335-339.
Strain(s): 144 
DOI: 10.1016/0922-338X(91)90346-I

Watanabe, M. M., Kasai, F., Hiwatari, T., Suda, S., Nei, T. 1984 Cryopreservation of microalgae in liquid nitrogen - Survival of algal cultures after freezing. Jpn. J. Freez. Dry., 30, 23-26 (in Japanese with English title).
Strain(s): 18,  19,  21,  24,  26,  29,  31,  39,  40,  41,  44,  45,  46,  50,  73,  74,  75,  76,  77,  80,  81,  87,  88,  89,  90,  91,  93,  95,  98,  99,  100,  101,  120,  122,  131,  135,  137,  144,  151,  204,  207,  213,  257,  263,  379,  415,  2219,  2235,  2239,  2579 

Ichimura, T. & Itoh, T. 1977 17. Preservation methods of microalgae (I) [17. Bisaisôrui no hozonhô (I)]. In Preservation methods of microorganisms [Biseibutsu Hozonhô], Ed. by Nei, T., University of Tokyo Press, Tokyo, pp. 355-373 (in Japanese).
Strain(s): 19,  21,  22,  23,  24,  27,  28,  30,  31,  32,  33,  34,  36,  37,  38,  39,  40,  41,  44,  45,  46,  47,  48,  49,  50,  122,  123,  127,  131,  144,  152,  173,  175,  179,  180,  181,  182,  183,  185,  198,  200,  203,  206,  217,  226,  227,  241,  266,  267,  268,  295,  309,  310,  334,  338,  379,  436,  448,  450,  455,  527 

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